EFFECT OF BLOOD PERFUSION ON THE ABLATION OF LIVER PARENCHYMA WITH HIGH-INTENSITY FOCUSED ULTRASOUND
EFFECT OF BLOOD PERFUSION ON THE ABLATION OF LIVER PARENCHYMA WITH HIGH-INTENSITY FOCUSED ULTRASOUND
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DOI：
10.1088/0031-9155/38/11/011
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发表时间：
1993-11-01
影响因子：
3.5
通讯作者：
BENSTED, JPM
中科院分区：
文献类型：
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作者：
CHEN, L;TERHAAR, G;BENSTED, JPM
探讨了血液灌注对高强度聚焦超声（HIFU）消融大鼠肝组织的影响。本研究提出了一种实用的方法，即结扎肝动脉和门静脉以减少肝血流量。在治疗过程中，将大鼠肝脏从腹腔中取出，并使用放射性微球法和激光多普勒血流监测仪测量血流。结果表明，通过肝动脉的肝血流量约为23 ml/100 g min-1，通过门静脉的肝血流量约为227 ml/100 g min-1。结扎肝动脉和门静脉后，肝血流量减少98%。使用1.7 MHz、67-425 W cm-2空间平均焦点强度I（SAL）和2-20 s暴露持续时间的聚焦超声束，在正常和血流减少的大鼠的相同肝叶上进行比较性损伤。在正常血流和血流减少情况下获得的病变尺寸之间存在显著差异。对于曝光在169 W cm-2的病变直径与正常血流减少了14%，为3 s曝光时间相比，获得与肝动脉和门静脉结扎，而减少超过20%，持续时间较长。
This paper discusses the effect of blood perfusion on the ablation of rat liver tissue with high-intensity focused ultrasound (HIFU). For this study a practical method has been developed, in which the liver blood flow can be reduced by ligation of the hepatic artery and portal vein. During the treatment the rat liver was mobilized out of the abdomen and the blood flow was measured using both the radioactive microsphere method and a laser Doppler blood-flow monitor. The results show that the hepatic blood flow was about 23 ml/100 g min-1 via the hepatic artery and about 227 ml/100 g min-1 via the portal vein. The total liver blood flow was reduced by 98% when both the hepatic artery and portal vein were ligated. Comparative lesions were made on the same liver lobes of rats with both normal and reduced blood flow using a focused ultrasound beam of 1.7 MHz, 67-425 W cm-2 spatially averaged focal intensity I(SAL) and 2-20 s exposure duration. A marked difference has been found between the lesion dimensions obtained with normal blood flow and that with reduced blood flow. For exposures at 169 W cm-2 the lesion diameter with normal blood flow was reduced by 14% for 3 s exposure duration compared to that obtained with both hepatic artery and portal vein ligated, while the reduction was more than 20% for longer durations.