Easy-to-Use Online Software Package for Internal Dose Assessment After Radionuclide Treatment in Clinical Routine
Easy-to-Use Online Software Package for Internal Dose Assessment After Radionuclide Treatment in Clinical Routine
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易于使用的在线软件包，用于临床常规放射性核素治疗后的内部剂量评估
DOI：
10.1097/rlu.0b013e31828da3db
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发表时间：
2013
影响因子：
10.6
通讯作者：
M. Diemling
中科院分区：
文献类型：
--
作者：
S. Mirzaei;A. Sohlberg;P. Knoll;R. Zakavi;M. Diemling
背景放射性核素治疗后的内剂量评估通常使用国产软件包进行。剂量评估包括图像配准、兴趣区域绘制、时间-活动曲线生成和人工计算停留时间，然后使用OLINDA/MIRD软件计算剂量。这些方法的缺点是，必须使用可能安装在不同工作站上的各种软件产品来执行几个步骤。上述方法容易出错，而且困难且耗时。在本文中，我们提出了一个商业软件包，在一个应用程序中实现了所有需要的剂量计算步骤，大大方便了内部剂量评估。方法与结果新开发的“混合剂量学”软件包的工作流程从图像自动配准到兴趣区域绘制，然后根据MIRD方法进行时间-活性曲线拟合和剂量计算。该软件可在线获得，并且可以使用通用DICOM格式的映像在独立计算机上运行。我们使用该包装对8例使用177Lu-DOTATATE治疗的患者进行了内剂量测定，并与人工剂量计算结果进行了比较。结论提供的在线软件包与平台无关，可以快速计算剂量。用新方法得到的结果与手工方法完全一致。
Background Internal dose assessment after radionuclide therapy is usually performed using home-made software packages. The dose assessment includes image registration, region-of-interest drawing, time-activity curve generation, and manual calculation of residence times followed by dose calculation with the OLINDA/MIRD software. The drawback of these methods is that several steps have to be performed using various software products possibly installed on different workstations. The aforementioned approaches are error-prone as well as difficult and time-consuming. In this article, we present a commercial software package that implements all the required dose calculation steps in 1 application, which greatly facilitates the internal dose assessment. Methods and Results The workflow of the newly developed software package “Hybrid Dosimetry” proceeds from automatic image registration to region-of-interest drawing, followed by time-activity curve fitting and dose calculation according to the MIRD method. The software is available online and can be run on independent computers using images in the common DICOM format. We used the package for internal dosimetry of 8 patients treated with 177Lu-DOTATATE and compared the results with manual dose calculation. Conclusions The online software package presented is platform independent and allows fast dose calculations. The results obtained with the new package were in perfect agreement with manual methods.