Learning from other people's fear: amygdala-based social reference learning in social anxiety disorder.
Learning from other people's fear: amygdala-based social reference learning in social anxiety disorder.
复制标题
DOI：
10.1017/s0033291716001537
复制
发表时间：
2016-10
影响因子：
6.9
通讯作者：
Pine, D. S.
中科院分区：
文献类型：
--
作者：
Blair, K. S.;Otero, M.;Teng, C.;Geraci, M.;Lewis, E.;Hollon, N.;Blair, R. J. R.;Ernst, Monique;Grillon, C.;Pine, D. S.
社交焦虑症涉及对社交对象或情境的恐惧。社会参照可能在获得这种恐惧中发挥重要作用，并可能成为未来生物标志物和治疗途径的关键决定因素。然而，在社交焦虑中介导这种学习的神经基础是未知的。利用事件相关功能磁共振成像，我们研究了社交焦虑障碍的社会参考学习。具体来说，患有这种疾病的患者是否会在社会参照学习过程中表现出杏仁核活动的增加，以及在社会参照学习之后，对与其他人的负面反应相关的物体表现出特别增加的反应？共有32名未经药物治疗的社交焦虑症患者和22名年龄，智商和性别匹配的健康个体对与他人的恐惧，愤怒，快乐或中性反应相关的物体做出反应。在社会参照学习阶段，一个显着的组×社会背景的相互作用表明，相对于对照组，社会焦虑组在社会参照试验中表现出显著更大的杏仁核反应，以及喙，背内侧和侧额叶和顶叶皮质。此外，在物体测试阶段，相对于对照组，社交焦虑组对与他人恐惧反应相关的物体表现出双侧杏仁核激活增加，而对与他人快乐和中性反应相关的物体表现出杏仁核激活减少的趋势。这些结果表明在社交焦虑障碍的干扰观察学习。此外，他们进一步暗示杏仁核和背内侧前额叶皮层在疾病中，并强调其在未来生物标志物发展中的重要性。
Social anxiety disorder involves fear of social objects or situations. Social referencing may play an important role in the acquisition of this fear and could be a key determinant in future biomarkers and treatment pathways. However, the neural underpinnings mediating such learning in social anxiety are unknown. Using event-related functional magnetic resonance imaging, we examined social reference learning in social anxiety disorder. Specifically, would patients with the disorder show increased amygdala activity during social reference learning, and further, following social reference learning, show particularly increased response to objects associated with other people’s negative reactions? A total of 32 unmedicated patients with social anxiety disorder and 22 age-, intelligence quotient- and gender-matched healthy individuals responded to objects that had become associated with others’ fearful, angry, happy or neutral reactions. During the social reference learning phase, a significant group × social context interaction revealed that, relative to the comparison group, the social anxiety group showed a significantly greater response in the amygdala, as well as rostral, dorsomedial and lateral frontal and parietal cortices during the social, relative to non-social, referencing trials. In addition, during the object test phase, relative to the comparison group, the social anxiety group showed increased bilateral amygdala activation to objects associated with others’ fearful reactions, and a trend towards decreased amygdala activation to objects associated with others’ happy and neutral reactions. These results suggest perturbed observational learning in social anxiety disorder. In addition, they further implicate the amygdala and dorsomedial prefrontal cortex in the disorder, and underscore their importance in future biomarker developments.