Concentration of ethanol and other volatile compounds in the blood of acutely poisoned alcoholics
Concentration of ethanol and other volatile compounds in the blood of acutely poisoned alcoholics
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DOI：
10.1016/s0741-8329(01)00186-0
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发表时间：
2002-01-01
期刊：
影响因子：
2.3
通讯作者：
Parczewski, A
中科院分区：
文献类型：
--
作者：
Zuba, D;Piekoszewski, W;Parczewski, A
对169例急性酒精中毒患者血液中的丙酮、乙醛、甲醇、乙醇、异丙醇、正丙醇等挥发性化合物进行了检测。成瘾的临床诊断是基于对患者的访谈以及生理、心理和精神检查。入院时，研究组血中乙醇平均浓度为3.14+/-1.10g/L，清除率为0.27+/-0.08g/kg/h，显著高于社会饮酒者平均0.014+/-0.04g/kg/h(P<；.001)。计算出甲醇的消除速率常数约为0.2h(-1)。这一速率似乎表明，在大量饮酒的人中，即使乙醇浓度高于1g/L，甲醇的消除也可能相对较快，其他挥发性化合物的消除可被大剂量的乙醇加速，尽管它与实际血液酒精水平无关。此外，在大多数甲醇浓度低于10毫克/L的血液样本中，丙酮浓度低于7毫克/L，异丙醇浓度低于2毫克/L。(C)2002年爱思唯尔科学公司版权所有。
The presence of volatile compounds, such as acetone, acetaldehyde, methanol, ethanol, isopropanol, and n-propanol, in the blood of 169 acutely poisoned alcoholics was determined. The clinical diagnosis of addiction was made on the basis of a patient interview as well as physical, psychological, and psychiatric examination. At the time of the patients' admission to the clinic, the mean concentration of ethanol in blood was 3.14 +/- 1.10 g/l and its elimination rate in the studied group was 0.27 +/- 0.08 g/kg/h, an elimination rate significantly higher (P < .001) than that of social drinkers, which averages to 0.014 +/- 0.04 g/kg/h. The presence of other volatile compounds in the blood of alcohol-addicted patients is common. The calculated elimination rate constant of methanol was about 0.2 h(-1). This rate seems to indicate that, in heavy drinkers, the elimination of methanol may be relatively fast even if the ethanol concentration is above I g/l. The elimination of other volatile compounds can be accelerated by large doses of ethanol, although it is not con-elated with actual blood ethanol level. Moreover, in most of the blood samples with a methanol concentration below 10 mg/l, the measured concentration of acetone was below 7 mg/l and that of isopropanol was below 2 mg/l. (C) 2002 Elsevier Science Inc. All rights reserved.