Catch and Release with DNA by Imidazolium-Presenting Iron Oxide Nanoparticles via Anion Exchange
Catch and Release with DNA by Imidazolium-Presenting Iron Oxide Nanoparticles via Anion Exchange
复制标题
通过阴离子交换咪唑呈现氧化铁纳米颗粒捕获并释放 DNA
DOI：
10.1080/15685543.2013.762891
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Y.
中科院分区：
文献类型：
--
作者：
Tanaka;K.; Narita;A.; Chujo;Y.
我们提出了通过阴离子交换使用咪唑呈递纳米颗粒的 DNA 捕获和释放技术。制备了咪唑系链超顺磁性氧化铁 (SPIO) 并研究了其与 DNA 的结合行为。因此，当咪唑鎓阳离子与亲水性阴离子如氯离子形成离子对时，DNA可以被吸附到修饰的SPIO上。相反，通过阴离子交换为疏水性阴离子（例如 TFSA−），结合亲和力大大降低，导致 DNA 释放。此外，通过在SPIO表面引入二氧化硅层可以提高释放效率。最后，在温和的条件下完成了DNA的捕获和释放。
We present the catch and release technique with DNA using imidazolium-presenting nanoparticles via anion exchange. The imidazolium-tethered superparamagnetic iron oxide (SPIO) was prepared and the binding behavior to DNA was investigated. Accordingly, when the imidazolium cation forms an ion pair with the hydrophilic anion such as chloride, DNA can be absorbed onto the modified SPIO. In contrast, by anion exchange to hydrophobic anion such as TFSA−, the binding affinity greatly decreased, resulting in the release of DNA. Moreover, the release efficiency can be improved by introducing a silica layer at the surface of SPIOs. Finally, the catch and release with DNA was accomplished under mild conditions.