Habitual aerobic exercise increases plasma pentraxin 3 levels in middle-aged and elderly women
Habitual aerobic exercise increases plasma pentraxin 3 levels in middle-aged and elderly women
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DOI：
10.1139/h2012-069
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发表时间：
2012-10-01
影响因子：
3.4
通讯作者：
Ajisaka, Ryuichi
中科院分区：
文献类型：
--
作者：
Miyaki, Asako;Maeda, Seiji;Ajisaka, Ryuichi
随着年龄的增长而发生的慢性炎症是心血管疾病的危险因素之一。经常锻炼可以通过减少慢性系统性炎症来预防心血管疾病。此外，抗炎蛋白pentraxin 3（PTX 3）可以减少过度炎症。因此，习惯性运动和PTX 3都具有抗炎作用。然而，目前尚不清楚定期运动是否会导致血浆PTX 3浓度增加。在本研究中，我们研究了定期有氧运动对中老年女性血浆PTX 3浓度的影响。将22名绝经后妇女（60 +/-6岁）随机平均分为2组（即，进行干预和控制）。运动组受试者完成2个月的常规有氧运动训练（步行和骑自行车，30-45分钟，3-5天.周（-1））。在干预前后，我们评估了所有参与者的血浆PTX 3浓度、峰值摄氧量、血液化学和动脉扩张性（颈动脉顺应性和β硬度）。两组之间的基线参数无显著差异。运动组干预后血浆PTX 3浓度显著升高（p < 0.05）。干预后高密度脂蛋白胆固醇、峰值摄氧量和动脉顺应性也显著增加（p < 0.05），而β硬度显著降低（p < 0.01）。另一方面，对照组中检测的参数无变化。这项研究表明，定期有氧运动增加血浆PTX 3浓度与改善高密度脂蛋白胆固醇，峰值摄氧量，动脉扩张性在绝经后妇女。
Chronic inflammation that occurs with aging is one of the risk factors for cardiovascular disease. Regular exercise may prevent cardiovascular morbidity by decreasing chronic systematic inflammation. Additionally, excess inflammation can be reduced by the anti-inflammatory protein pentraxin 3 (PTX3). Thus, both habitual exercise and PTX3 have an anti-inflammatory effect. However, it is unclear whether regular exercise leads to increased plasma PTX3 concentration. In the present study, we investigated the effects of regular aerobic exercise on plasma PTX3 concentration in middle-aged and elderly women. Twenty-two postmenopausal women (60 +/- 6 years) were randomly divided evenly into 2 groups (i.e., exercise intervention and control). Subjects in the exercise group completed 2 months of regular aerobic exercise training (walking and cycling, 30-45 min, 3-5 days.week(-1)). Before and after the intervention, we evaluated plasma PTX3 concentration, peak oxygen uptake, blood chemistry, and arterial distensibility (carotid arterial compliance and beta-stiffness) in all participants. There were no significant differences in baseline parameters between the 2 groups. Plasma PTX3 concentration was significantly increased in the exercise group after the intervention (p < 0.05). High-density lipoprotein cholesterol, peak oxygen uptake, and arterial compliance were also significantly increased (p < 0.05), while beta-stiffness was markedly decreased (p < 0.01) after the intervention. On the other hand, there was no change in the parameters tested in the control group. This study demonstrates that regular aerobic exercise increases plasma PTX3 concentration with improvement of high-density lipoprotein cholesterol, peak oxygen uptake, and arterial distensibility in postmenopausal women.