Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts
Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts
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DOI：
10.1182/blood-2006-05-024364
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发表时间：
2007-02-01
期刊：
影响因子：
20.3
通讯作者：
Silvestri, Guido
中科院分区：
文献类型：
--
作者：
Pandrea, Ivona;Apetrei, Cristian;Silvestri, Guido
与人类和猕猴的慢病毒感染相反，尽管病毒复制水平很高，但自然宿主的猿猴免疫缺陷病毒（SIV）感染是非致病性的。然而，这种无疾病的机制尚不清楚。在这里，我们报道了SIV感染的天然宿主在从血液、淋巴结和粘膜组织中分离的CD 4（+）T细胞上表达非常低水平的CCR 5。鉴于这种免疫学特征存在于5种不同的天然SIV宿主（白眉猴、非洲绿色猴、山海关猴、阳尾猴和黑猩猩）中，但在5种正常/近期宿主（人类、恒河猴、猪尾猴、食蟹猴和狒狒）中不存在，它可能代表了病毒与其天然宿主之间共同进化的关键特征，导致了非致病性感染。CCR 5在CD 4（+）T细胞上的低表达的有益作用可能包括减少用于病毒复制的靶细胞和减少活化的CD 4（+）T细胞向发炎组织的归巢。
In contrast to lentiviral infections of humans and macaques, simian immunodeficiency virus (SIV) infection of natural hosts is nonpathogenic despite high levels of viral replication. However, the mechanisms underlying this absence of disease are unknown. Here we report that natural hosts for SIV infection express remarkably low levels of CCR5 on CD4(+) T cells isolated from blood, lymph nodes, and mucosal tissues. Given that this immunologic feature is found in 5 different species of natural SIV hosts (sooty mangabeys, African green monkeys, mandrills, sun-tailed monkeys, and chimpanzees) but is absent in 5 normatural/recent hosts (humans, rhesus, pigtail, cynomolgus macaques, and baboons), it may represent a key feature of the coevolution between the virus and its natural hosts that led to a nonpathogenic infection. Beneficial effects of low CCR5 expression on CD4(+) T cells may include the reduction of target cells for viral replication and a decreased homing of activated CD4(+) T cells to inflamed tissue.