Psychopathology in drug abusers and their families.
Psychopathology in drug abusers and their families.
复制标题
吸毒者及其家人的精神病理学。
DOI：
10.1016/0010-440x(91)90068-n
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发表时间：
1991
影响因子：
7.3
通讯作者：
Michael,JL
中科院分区：
文献类型：
--
作者：
Mirin,SM;Weiss,RD;Griffin,ML;Michael,JL
350例住院药物依赖患者的人口统计学、临床和家族谱系数据显示，52%的患者符合DSM-III酒精滥用或依赖标准，而37%的患者符合DSM-III药物滥用以外的并发轴I精神障碍标准。循环情感障碍在可卡因滥用者中更为常见，而广泛性焦虑障碍和惊恐障碍在镇静催眠药物滥用者中更为常见。对1,478名一级亲属的数据显示，酒精中毒和情感障碍的患病率与先证者类似精神病理学的发生高度相关。这些研究结果表明，药物的选择和共病的精神病理学之间的关系，在这些疾病的传播的家族因素的作用，和诊断亚型的重要性，在评估和治疗药物滥用者。
Demographic, clinical, and family pedigree data obtained on 350 hospitalized drug-dependent patients showed that 52% also met DSM-III criteria for alcohol abuse or dependence, while 37% met DSM-III criteria for a concurrent axis I psychiatric disorder other than substance abuse. Cyclothymic disorder was significantly more common among cocaine abusers, while generalized anxiety disorder and panic disorder were more common among sedative-hypnotic abusers. Data on 1,478 first-degree relatives revealed that the prevalence of alcoholism and affective disorder was highly correlated with the occurrence of similar psychopathology in the probands. These findings suggest a relationship between drug of choice and comorbid psychopathology, a role for familial factors in the transmission of these disorders, and the importance of diagnostic subtypes in the evaluation and treatment of substance abusers.