The First Full-Length Endogenous Hepadnaviruses: Identification and Analysis
The First Full-Length Endogenous Hepadnaviruses: Identification and Analysis
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第一个全长内源性肝炎病毒：鉴定和分析
DOI：
10.1128/jvi.01164-12
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发表时间：
2012-09-01
影响因子：
5.4
通讯作者：
Xie, Youhua
中科院分区：
文献类型：
--
作者：
Liu, Wei;Pan, Shaokun;Xie, Youhua
在后生动物基因组数据的计算机筛选中，发现了虎皮鹦鹉（Melopsittacus波动）基因组中的多个内源性肝病毒元件，其中最值得注意的两个元件分别占全长基因组的1.3倍和1.0倍。系统发育和分子定年分析表明，内源性虎皮猴乙型肝炎病毒（eBHBV）与现存的虎皮猴病毒有共同的祖先，并在数百万年前侵入虎皮猴基因组。鉴定具有保留关键特征（如epsilon信号）的全长基因组可以使古代BHBV复活。
In silico screening of metazoan genome data identified multiple endogenous hepadnaviral elements in the budgerigar (Melopsittacus undulatus) genome, most notably two elements comprising about 1.3 x and 1.0 x the full-length genome. Phylogenetic and molecular dating analyses show that endogenous budgerigar hepatitis B viruses (eBHBV) share an ancestor with extant avihepadnaviruses and infiltrated the budgerigar genome millions of years ago. Identification of full-length genomes with preserved key features like epsilon signals could enable resurrection of ancient BHBV.