IgG4 expression in patients with eosinophilic otitis media
IgG4 expression in patients with eosinophilic otitis media
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嗜酸性粒细胞性中耳炎患者IgG4的表达
DOI：
10.1159/000512726
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Okano M
中科院分区：
文献类型：
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作者：
Takahashi M;Oka A; Kariya S; Gion Y;Sato Y; Iwasaki S;Oyamada S;Matsubara A;Okano M
嗜酸性中耳炎（EOM）是一种难治性中耳疾病，其特征是中耳积液和粘膜中嗜酸性粒细胞增多。虽然EOM的确切发病机制尚不清楚，但其特征在于2型炎症。由于IgG 4是一个IgG亚类诱导的2型细胞因子，如IL-4和IL-13，我们试图表征和比较局部IgG 4表达的患者和没有眼外膜。MethodsTwelve例双侧极重度听力损失，其中9例进行了人工耳蜗植入手术，参加了这项研究（6眼外膜和6没有眼外膜）。结果EOM患者中耳黏膜中存在大量IgG 4阳性细胞，其阳性细胞数明显高于非EOM患者。结论EOM患者局部IgG 4表达高于非EOM患者，提示IgG 4参与了EOM的发病过程。
ObjectiveEosinophilic otitis media (EOM) is an intractable middle ear disease recognized by an eosinophil enriched middle ear effusion and mucosa. Although precise pathogenesis of EOM remains unclear, it is characterized by type 2 inflammation. Since IgG4 is an IgG subclass induced by type 2 cytokines such as IL-4 and IL-13, we sought to characterize and compare local IgG4 expression in patients with and without EOM.MethodsTwelve patients with bilateral profound hearing loss, 9 of which underwent a cochlear implant surgery, were enrolled in this study (6 with EOM and 6 without EOM). The surgical specimens were harvested during surgery and were subjected to IgG4 immunostaining.ResultThe middle ear mucosa showed the presence of a large number of IgG4-positive cells in patients with EOM, which was significantly higher than that in patients without EOM.ConclusionLocal IgG4 expression was observed in patients with EOM in comparison to those without EOM, suggesting that IgG4 contributes to EOM pathogenesis.