EFFECT OF TETRABENAZINE ON EXTRAPYRAMIDAL MOVEMENT DISORDERS
EFFECT OF TETRABENAZINE ON EXTRAPYRAMIDAL MOVEMENT DISORDERS
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DOI：
10.1136/bmj.2.5654.422
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发表时间：
1969-01-01
影响因子：
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通讯作者：
DALBY, MA
中科院分区：
文献类型：
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作者：
DALBY, MA
30例各种锥体外系运动障碍患者接受75 - 225 mg长期治疗。每日服用丁苯那嗪在舞蹈样和偏侧运动活动的患者中，不自主运动减少或消失。在小脑或帕金森震颤患者中，震颤在中度严重病例中加重，但在严重病例中不受影响。在所有的病例中，运动障碍在停药后都会复发，副作用很小，在稍微减少剂量后就消失了。因此，该药物可能是神经外科治疗运动过度的重要替代方案，特别适用于严重残疾患者。
Thirty patients with various extrapyramidal movement disorders were treated for prolonged periods with 75 to 225 mg. daily of tetrabenazine. In patients with choreiform and hemiballistic motor activity the involuntary movements were diminished or abolished. In patients with cerebellar or Parkinsonian tremor the tremor was aggravated in moderately severe cases, but was uninfluenced in severe cases. In all cases the dyskinesia returned when- the drug was stopped.Side-effects were inconsiderable and disappeared on reducing the dose slightly. Hence the drug may be an important alternative to neurosurgical treatment of hyperkinesias and especially suitable for severely disabled patients.