The effect of ovarian sex steroids on bone mineral status in the oöphorectomized rat and in the human.
The effect of ovarian sex steroids on bone mineral status in the oöphorectomized rat and in the human.
复制标题
卵巢性类固醇对卵巢切除大鼠和人类骨矿物质状态的影响。
DOI：
--
复制
发表时间：
1978
影响因子：
5.1
通讯作者：
D. Purdie
中科院分区：
文献类型：
--
作者：
R. Lindsay;Aitken Jm;Hart Dm;D. Purdie
研究了卵巢切除术和卵巢切除术后激素替代疗法对大鼠股骨和椎骨骨矿物质的影响。卵巢切除术导致股骨骨质疏松，但第七尾椎没有骨质疏松。服用孕激素（乙炔二醇二乙酸酯 9 微克/天）显然可以防止股骨骨矿物质含量的损失。这是由于骨膜骨形成增加和股骨变宽所致。雌激素（美雌醇0.9微克/天）对股骨骨质疏松症没有显着影响，但增加了椎骨的骨矿物质含量。雌激素和孕激素联合治疗对骨矿物质含量的任何参数均没有影响。初步人体研究表明，孕激素在预防绝经后骨质流失方面可能与雌激素一样有效。没有证据表明孕激素会减少骨吸收（如尿羟脯氨酸排出量所示），因此推测孕激素可能通过刺激骨形成来延缓绝经后时期的骨质流失。
The effect of oöphorectomy and hormone replacement therapy after oöphorectomy on bone mineral in the femur and vertebra of the rat has been studied. Oöphorectomy resulted in osteoporosis of the femur but not of the seventh caudal vertebra. The administration of a progestogen (ethynodiol diacetate 9 microgram/day) apparently prevented loss of bone mineral content of the femur. This was due to increased periosteal bone formation and widening of the femur. An oestrogen (mestranol 0.9 microgram/day) had no significant effect on the femoral osteoporosis but increased bone mineral content of the vertebra. Combined therapy with oestrogen and progestogen had no effect on any parameter of bone mineral content. The preliminary human study indicated that a progestogen may also be as effective as an oestrogen in prevention of post-menopausal bone loss. There was no evidence of reduction of bone resorption (as indicated by urinary hydroxyproline output) by the progestogen and therefore it is postulated that a progestogen might retard bone loss in the post-menopausal era by stimulating bone formation.