Excess All-Cause and Cause-Specific Mortality Among People with Diabetes During the COVID-19 Pandemic in Minnesota: Population-Based Study.
Excess All-Cause and Cause-Specific Mortality Among People with Diabetes During the COVID-19 Pandemic in Minnesota: Population-Based Study.
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DOI：
10.1007/s11606-022-07709-9
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发表时间：
2022-09
影响因子：
5.7
通讯作者：
Campbell, Ronna L.
中科院分区：
文献类型：
--
作者：
McCoy, Rozalina G.;Mullan, Aidan F.;Jeffery, Molly M.;Bucks, Colin M.;Clements, Casey M.;Campbell, Ronna L.
对2018年至2019年和2020年的明尼苏达州死亡证明进行了检查，以确定糖尿病患者是主要或促成（列出的所有原因中）死亡的原因。然后根据主要死因对死亡进行分类;然而，将COVID-19列为五大死因之一的死亡被分类为COVID-19死亡。使用明尼苏达州3的人口统计数据计算每10万糖尿病患者的死亡率，并使用发病率比和95%置信区间进行时间段之间的比较。敏感性分析分别检查了2018年、2019年和2020年的全因和糖尿病酮症酸中毒（DKA）/高血糖高渗状态（HHS）死亡。使用双侧Fisher精确检验和卡方检验（使用Benjamini-Hochberg校正进行调整）比较人口统计学和死亡特征。4这项研究免于机构委员会审查，因为数据是公开的，所有受试者都已死亡，并且没有包括可识别的信息。2020年，每10万名明尼苏达州糖尿病患者中有246人死亡（表1）。全因死亡率从每10万人1，484人增加到1，922人（IRR 1.30 [95%CI 1.26-1.33]），2019年至2020年期间增加最多。于二零二零年，糖尿病为主要死因的死亡人数中，由糖尿病酮症酸中毒/高血压引起的比例下降（二零一八年：5. 09%;二零一九年：5. 43%;二零二零年：4. 85%）。非COVID死亡率从1，484/100，000增加到1，675/100，000（IRR 1.13 [95%CI 1.10-1.16]）。以糖尿病为主要原因的死亡人数略有增加（IRR 1.08 [95% CI 1.01-1.15]）;经多重比较校正后，这一点不显著（校正P值0.07）。然而，心血管疾病（IRR 1.08 [95%CI，1.02-1.15]）、癌症（IRR 1.27 [95%CI，1.17-1.37]）和非COVID-19感染性疾病（IRR 1.47 [95%CI，1.18-1.84]）的死亡人数增加了统计学显著性数量。
METHODSMinnesota death certificates from 2018 to 2019 and 2020 were examined to identify those with diabetes as the primary or contributing (among all causes listed) cause of death. Deaths were then classified based on the primary cause of death; however, deaths listing COVID-19 among the top five contributing causes were classified as COVID-19 deaths. Deaths per 100,000 people with diabetes were calculated using population statistics for Minnesota 3 and compared between time periods using incidence rate ratios with 95% confidence intervals. Sensitivity analyses examined all-cause and diabetic ketoacidosis (DKA)/hyperglycemic hyperosmolar state (HHS) deaths for 2018, 2019, and 2020 separately. Demographics and death characteristics were compared using two-sided Fisher’s exact and chi-squared tests adjusted using the Benjamini-Hochberg correction. 4 This study was exempt from Institutional Board Review because data was publicly available, all subjects are deceased, and no identifiable information was included.RESULTSCOVID-19 resulted in 246 deaths per 100,000 Minnesotans with diabetes in 2020 (Table 1). All-cause mortality increased from 1,484 to 1,922 per 100,000 (IRR 1.30 [95% CI 1.26–1.33]), increasing most between 2019 and 2020. The proportion of deaths with diabetes as the primary cause that were caused by DKA/HHS decreased in 2020 (2018: 5.09%; 2019: 5.43%; 2020: 4.85%). Non-COVID mortality increased from 1,484 to 1,675 per 100,000 (IRR 1.13 [95% CI 1.10–1.16]). Deaths with diabetes as the primary cause increased slightly (IRR 1.08 [95% CI 1.01–1.15]); this was not significant after adjustment for multiple comparisons (corrected P-value 0.07). However, deaths from cardiovscular disease (IRR 1.08 [95% CI, 1.02–1.15]), cancer (IRR 1.27 [95% CI, 1.17–1.37]), and non-COVID-19 infectious diseases (IRR 1.47 [95% CI, 1.18–1.84]) increased by statistically significant amounts.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
168.9
作者：
Gregg, Edward W.;Cheng, Yiling J.;Imperatore, Giuseppina
通讯作者：
Imperatore, Giuseppina
影响因子：
168.9
作者：
Banerjee, Amitava;Pasea, Laura;Hemingway, Harry
通讯作者：
Hemingway, Harry