An association between asthma and TNF-308G/A polymorphism: meta-analysis.
An association between asthma and TNF-308G/A polymorphism: meta-analysis.
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DOI：
10.1007/s10038-006-0007-3
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发表时间：
2006-01-01
影响因子：
3.5
通讯作者：
Noguchi, Emiko
中科院分区：
文献类型：
--
作者：
Aoki, Takeshi;Hirota, Tomomitsu;Noguchi, Emiko
肿瘤坏死因子（TNF）是一种强有力的炎症细胞因子，有助于哮喘的气道炎症。先前的研究已经报道了位置-308（-308G/A，也分别称为TNF-α-308 *1和308*2）处的G到A转换与哮喘相关，但其他研究显示了相互矛盾的结果。为了研究TNF-308 G/A多态性与哮喘之间的可能关联，我们进行了传递不平衡检验和病例对照研究（家庭样本：165个日本三人家庭中的495名成员，其中一名哮喘儿童和双亲;病例对照样本：461名日本哮喘儿童和465名健康对照）。为了增加样本量和功效，我们对所有可用的相关研究进行了荟萃分析，包括2，477例哮喘患者和3，217例对照。在两个独立的日本人群中，我们没有发现TNF-308 G/A多态性与儿童特应性哮喘之间的显著关联（P>0.05）;然而，荟萃分析显示TNF-308 G/A多态性与哮喘有统计学显著相关。TNF-308 A的固定效应模型和随机效应的组合比值比分别为1.46（95%置信区间[CI]，1.27-1.68，P= 0.000001）和1.46（95% CI，1.20-1.77，P=0.00014）。我们的数据进一步支持TNF区域在哮喘发展中的重要性。
Tumor necrosis factor (TNF) is a potent inflammatory cytokine that contributes to airway inflammation in asthma. Previous studies have reported that a G-to-A transition at position -308 (-308G/A, also referred to as TNF-alpha-308*1 and 308*2 respectively), is associated with asthma, but other studies have shown conflicting results. To investigate a possible association between the TNF-308G/A polymorphism and asthma, we performed transmission disequilibrium tests and a case-control study (family samples: 495 members in 165 Japanese trio families with one asthmatic child and both parents; case-control samples: 461 Japanese asthmatic children and 465 healthy controls). To increase the sample size and power, we performed a meta-analysis of all available relevant studies, including 2,477 asthmatics and 3,217 controls. We did not find a significant association between the TNF-308G/A polymorphism and childhood atopic asthma in two independent Japanese populations (P>0.05); however, meta-analysis revealed that the TNF-308G/A polymorphism was statistically significantly associated with asthma. The combined odds ratio with a fixed effects model and with a random effects for TNF-308A was 1.46 (95% confidence interval [CI], 1.27-1.68, P=0.0000001) and 1.46 (95% CI, 1.20-1.77, P=0.00014) respectively. Our data further support the importance of the TNF region in the development of asthma.