Prevalence of Influenza A viruses in wild migratory birds in Alaska: patterns of variation in detection at a crossroads of intercontinental flyways.
Prevalence of Influenza A viruses in wild migratory birds in Alaska: patterns of variation in detection at a crossroads of intercontinental flyways.
复制标题
阿拉斯加野生迁徙鸟类中流感A病毒的流行：在洲际飞行道的十字路口检测模式。
DOI：
10.1186/1743-422x-5-71
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发表时间：
2008-06-04
期刊：
影响因子：
4.8
通讯作者：
Rothe, Thomas C.
中科院分区：
文献类型：
--
作者：
Ip, Hon S.;Flint, Paul L.;Franson, J. Christian;Dusek, Robert J.;Derksen, Dirk V.;Gill, Robert E., Jr.;Ely, Craig R.;Pearce, John M.;Lanctot, Richard B.;Matsuoka, Steven M.;Irons, David B.;Fischer, Julian B.;Oates, Russell M.;Petersen, Margaret R.;Fondell, Thomas F.;Rocque, Deborah A.;Pedersen, Janice C.;Rothe, Thomas C.
高致病性禽流感H5 N1病毒在全球的传播激发了人们对更好地了解H5 N1传播机制的兴趣，包括候鸟作为携带者的潜在作用。虽然野鸟在H5 N1爆发期间被发现死亡，但有证据表明，其他野鸟在自然感染中幸存下来，最近的研究表明，几种鸭子能够在H5 N1实验性接种中幸存下来并脱落病毒。为了调查候鸟作为H5 N1病毒传播到北美的一种途径的可能性，我们根据野鸟可能携带来自亚洲的病毒的风险，在一项监测计划中监测了该病毒。2006年5月至2007年3月在阿拉斯加州采集的16,797份禽类样品中，用rRT-PCR方法检测到1.7%的低致病性禽流感病毒，但未发现高致病性病毒。（水鸟最高，雀形目最低），年龄（青少年高于成年人），性别（男性高于女性），日期（秋季最高）和分析技术（rRT-PCR流行率= 1.7%;病毒分离流行率= 1.5%）。从野鸟中分离的低致病性禽流感病毒的流行取决于生物、时间和地理因素以及检测方法。未来的研究应该控制或抽样这些变异来源，以便直接比较患病率。
The global spread of the highly pathogenic avian influenza H5N1 virus has stimulated interest in a better understanding of the mechanisms of H5N1 dispersal, including the potential role of migratory birds as carriers. Although wild birds have been found dead during H5N1 outbreaks, evidence suggests that others have survived natural infections, and recent studies have shown several species of ducks capable of surviving experimental inoculations of H5N1 and shedding virus. To investigate the possibility of migratory birds as a means of H5N1 dispersal into North America, we monitored for the virus in a surveillance program based on the risk that wild birds may carry the virus from Asia. Of 16,797 birds sampled in Alaska between May 2006 and March 2007, low pathogenic avian influenza viruses were detected in 1.7% by rRT-PCR but no highly pathogenic viruses were found. Our data suggest that prevalence varied among sampling locations, species (highest in waterfowl, lowest in passerines), ages (juveniles higher than adults), sexes (males higher than females), date (highest in autumn), and analytical technique (rRT-PCR prevalence = 1.7%; virus isolation prevalence = 1.5%). The prevalence of low pathogenic avian influenza viruses isolated from wild birds depends on biological, temporal, and geographical factors, as well as testing methods. Future studies should control for, or sample across, these sources of variation to allow direct comparison of prevalence rates.