FAMILIAL CANCER HISTORY AND CHRONIC LYMPHOCYTIC-LEUKEMIA - A CASE-CONTROL STUDY
FAMILIAL CANCER HISTORY AND CHRONIC LYMPHOCYTIC-LEUKEMIA - A CASE-CONTROL STUDY
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DOI：
10.1093/oxfordjournals.aje.a115387
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发表时间：
1989-10-01
影响因子：
5
通讯作者：
SZKLO, M
中科院分区：
文献类型：
--
作者：
LINET, MS;VANNATTA, ML;SZKLO, M
在马里兰州巴尔的摩都会区进行的一项以人群为基础的病例对照研究中，1969-1982 年诊断的 342 例慢性淋巴细胞白血病病例的家族癌症史显示，与报告的在 1969 年至 1982 年报告的发生这些肿瘤的情况相比，他们的一级亲属患白血病以及其他造血淋巴增殖性肿瘤和乳腺癌的风险显着更高。 342 名匹配的癌症对照者和 342 名匹配的无癌症对照者的一级亲属。与对照组的兄弟姐妹相比，病例受试者的兄弟姐妹的肾癌发病率也显着升高。只有一个受影响的病例家庭（没有对照家庭）包括一名以上患有白血病的成员。结果表明，尽管大多数慢性粒细胞白血病病例似乎是散发性的，但几个病例家族中白血病的发生存在遗传因素。两次比较（病例与癌症对照以及病例与无癌症对照）之间的相似性降低了回忆偏差的可能性，而回忆偏差是观察到的过度风险的解释。
In a population-based case-control study carried out in the Baltimore, Maryland metropolitan area, family cancer history for 342 chronic lymphocytic leukemia cases diasgnosed in 1969-1982 revealed significantly higher risks of leukemia as well as other hematolymphoproliferative neoplasms and breast cancer among their first-degree relatives compared with reported occurrence of these neoplasms in first-degree relatives of 342 matched cancer controls and 342 matched controls without cancer. Siblings of case subjects also had a significant elevation of kidney cancer compared with siblings of controls. Only one of the affected case families (and no control family) included more than one additional member with leukemia. The results suggest a genetic component for leukemia occurrence in several case families, although the majority of cases of chronic lumphocytic leukemia appeared to be sporadic. The similarity of findings between the two comparisons (cases vs. cancer controls and cases vs. controls without cancer) diminishes the likelihood of recall bias an explanation for the observed excess risks.