INVARIANT CHAIN DISTINGUISHES BETWEEN THE EXOGENOUS AND ENDOGENOUS ANTIGEN PRESENTATION PATHWAYS
INVARIANT CHAIN DISTINGUISHES BETWEEN THE EXOGENOUS AND ENDOGENOUS ANTIGEN PRESENTATION PATHWAYS
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DOI：
10.1038/348039a0
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发表时间：
1990-11-01
期刊：
影响因子：
64.8
通讯作者：
PETERSON, PA
中科院分区：
文献类型：
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作者：
TEYTON, L;OSULLIVAN, D;PETERSON, PA
I类MHC分子从内源性合成的蛋白质中获得肽，而II类抗原则从细胞外分子中获得肽。这种二分法是由于不变链与内质网中的II类分子结合，阻止内源性肽的结合。肽和不变链与II类分子的互斥结合表明，不变链可能在自身免疫性疾病中发挥作用。
Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, preventing binding of endogenous peptides. The mutually exclusive binding of peptide and invariant chain to class II molecules suggests that the invariant chain might play a part in autoimmune disease.