Sarcopenic obesity and inflammation in the InCHIANTI study
Sarcopenic obesity and inflammation in the InCHIANTI study
复制标题
DOI：
10.1152/japplphysiol.00627.2006
复制
发表时间：
2007-03-01
影响因子：
3.3
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
--
作者：
Schrager, Matthew A.;Metter, E. Jeffrey;Ferrucci, Luigi
衰老过程通常伴随着肌肉的减少和脂肪量的增加。在极端情况下，这两个过程导致一种称为“肌肉减少性肥胖”的状况（Roubenoff R. Ann NY Acad Sci 904：553-557，2000）。研究表明，脂肪组织，特别是内脏脂肪产生的炎性细胞因子，加速肌肉分解，从而导致恶性循环，引发和维持肌肉减少性肥胖。我们测试的假设，肥胖和肌肉力量差，肌肉减少性肥胖的标志，与高循环水平的促炎细胞因子在基安蒂地理区域（托斯卡纳，意大利）的两个城市的居民的随机样本。研究样本包括378名男性和493名女性，年龄65岁及以上，具有人体测量学、握力和炎症标志物的完整数据。根据腰围和握力的性别特异性三分位数以及体重指数≥ 30 kg/m2的肥胖分界点对参与者进行交叉分类。在调整年龄、性别、教育、吸烟史、体力活动和共病史后，肌肉减少性肥胖与IL-6、C反应蛋白、IL-1受体拮抗剂和可溶性IL-6受体水平升高相关（P < 0.05）。我们的研究结果表明，整体肥胖，在更大程度上，中心性肥胖直接影响炎症，这反过来又对肌肉力量产生负面影响，有助于肌肉减少性肥胖的发展和进展。这些结果表明，促炎细胞因子可能是至关重要的肌肉减少性肥胖的发展和进展。
The aging process is often paralleled by decreases in muscle and increases in fat mass. At the extreme these two processes lead to a condition known as "sarcopenic obesity" (Roubenoff R. Ann NY Acad Sci 904: 553-557, 2000). Research suggests that inflammatory cytokines produced by adipose tissue, especially visceral fat, accelerate muscle catabolism and thus contribute to the vicious cycle that initiates and sustains sarcopenic obesity. We tested the hypothesis that obesity and poor muscle strength, hallmarks of sarcopenic obesity, are associated with high circulating levels of proinflammatory cytokines in a random sample of the residents of two municipalities in the Chianti geographic area (Tuscany, Italy). The study sample consisted of 378 men and 493 women 65 yr and older with complete data on anthropometrics, handgrip strength, and inflammatory markers. Participants were cross-classified according to sex-specific tertiles of waist circumference and grip strength and according to a cut point for obesity of body mass index >= 30 kg/m(2). After adjusting for age, sex, education, smoking history, physical activity, and history of comorbid diseases, components of sarcopenic obesity were associated with elevated levels of IL-6, C-reactive protein, IL-1 receptor antagonist, and soluble IL-6 receptor (P < 0.05). Our findings suggest that global obesity and, to a greater extent, central obesity directly affect inflammation, which in turn negatively affects muscle strength, contributing to the development and progression of sarcopenic obesity. These results suggest that proinflammatory cytokines may be critical in both the development and progression of sarcopenic obesity.