SYSTEMIC EFFECTS OF EPINEPHRINE APPLIED TOPICALLY TO THE EYE
SYSTEMIC EFFECTS OF EPINEPHRINE APPLIED TOPICALLY TO THE EYE
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肾上腺素局部应用于眼睛的全身效应
DOI：
10.1097/00132586-196708000-00015
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发表时间：
1966
期刊：
影响因子：
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通讯作者：
J. Bonica
中科院分区：
文献类型：
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作者：
N. Ballin;B. Becker;M. Goldman;J. Bonica
局部眼部使用肾上腺素已被证明与心脏外收缩频率增加相关。虽然通常认为是良性的，但这种期外收缩为局部应用肾上腺素的全身吸收和对心脏的直接影响提供了证据。为了避免已知在相似剂量的肾上腺素全身给药后发生的更严重的心脏毒性作用，建议在已知患有心脏病、甲状腺功能亢进症或对肾上腺素全身作用异常敏感的患者中谨慎使用肾上腺素。
The topical ocular use of epinephrine has been shown to be correlated with an increased frequency of cardiac extrasy stoles. While generally considered benign, such extrasystoles provide evidence for the systemic absorption of topically applied epinephrine and a direct effect on the heart. In order to avoid the more serious cardiotoxic effects known to occur following systemic administration of epinephrine in comparable dosages, it is suggested that epinephrine be used cautiously in patients with known heart disease, hyperthyroidism, or abnormal sensitivity to the systemic effects of epinephrine.