Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease
Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease
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DOI：
10.1016/j.archoralbio.2014.08.021
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发表时间：
2015-01-01
影响因子：
3
通讯作者：
Emingil, Gulnur
中科院分区：
文献类型：
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作者：
Kursunlu, Sabri Fatih;Ozturk, Veli Ozgen;Emingil, Gulnur
背景：牙周炎症是由包括 IL-1 家族在内的多种因素的协调作用驱动的。我们的研究旨在检测不同牙周病患者龈沟液（GCF）中白细胞介素（IL）-36β、IL-36γ和IL-33的水平。材料和方法：总共80名受试者，其中20名广泛侵袭性牙周炎（G-AgP）患者，20名慢性牙周炎（CP）患者，20名牙龈炎患者和20名牙周病患者。健康受试者也被纳入其中。通过测量探诊深度、临床附着丧失、乳头出血指数和菌斑指数来评估牙周状态。通过ELISA分析GCF细胞因子水平。结果：CP组、牙龈炎组和健康组具有相似的GCF IL-36β总量（p>0.008）。与 CP 组相比，G-AgP 组的 IL-36 β 总量升高（p < 0.008）。 G-AgP组与牙龈炎组和健康组具有相似的GCF IL-36β总量（p>0.008）。研究组的GCF IL-36 γ和IL-33总量相似（p>0.05）。结论：本研究首次证明不同牙周疾病中IL-36 β、IL-36 γ和IL-33 GCF水平的存在。与 CP 组相比，AgP 组的 IL-36-β 水平较高，这可能表明侵袭性牙周炎可能与 GCF IL-36 beta 的增加有关。 (C) 2014 Elsevier Ltd. 保留所有权利。
Background: Periodontal inflammation is driven by the coordinated action of a number of factors, including the IL-1 family. Our study aimed to examine the levels of interleuldn (IL)-36 beta, IL-36 gamma and IL-33 levels in gingival crevicular fluid (GCF) from patients with different periodontal diseases.Materials and methods: A total of 80 subjects, 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with chronic periodontitis (CP), 20 with gingivitis and 20 periodontally healthy subjects were included. Periodontal status was evaluated by measuring probing depth, clinical attachment loss, papillary bleeding index and plaque index. GCF cytokine levels were analysed by ELISA.Results: CP, gingivitis and healthy groups had similar GCF IL-36 beta total amount (p > 0.008). G-AgP group had elevated IL-36 beta total amount compared to CP group (p < 0.008). G-AgP group had similar GCF IL-36 beta total amount to gingivitis and healthy groups (p > 0.008). GCF IL-36 gamma and IL-33 total amounts of the study groups were similar (p > 0.05).Conclusions: The present study demonstrated for the first time the presence of IL-36 beta, IL-36 gamma and IL-33 GCF levels with different periodontal diseases. High levels of IL-36-beta in the AgP group in comparison to CP group might suggest that periodontitis in the aggressive form could be related to the increase in GCF IL-36 beta. (C) 2014 Elsevier Ltd. All rights reserved.