The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE)
The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE)
复制标题
DOI：
10.1016/j.npep.2011.01.005
复制
发表时间：
2011-06-01
期刊：
影响因子：
2.9
通讯作者：
Kostyra, Elzbieta
中科院分区：
文献类型：
--
作者：
Wasilewska, Jolanta;Sienkiewicz-Szlapka, Edyta;Kostyra, Elzbieta
酪蛋白衍生的多肽被认为在婴儿猝死综合征(SID)中发挥作用。在这项研究中，我们测定了有明显生命威胁事件(Alte综合征)的婴儿血清中牛β-酪啡肽-7(bBCM-7)的含量和二肽基多肽酶-IV(DPPIV)的活性。我们发现，在发生呼吸暂停事件后，一些婴儿的血清中含有比同年龄段的健康婴儿更多的β-酪啡肽-7。然而，在发生呼吸暂停事件后的所有儿童中，都检测到DPPIV降低。我们推测，该肽酶的低活性可能与阿片类药物引起的呼吸抑制有关，这种呼吸抑制是由bBCM-7在全身循环中诱导的。(C)2011爱思唯尔有限公司。保留所有权利。
Casein-derived peptides have been suggested to play a role in sudden infant death syndrome (SIDS). In this study, we have determined the content of bovine beta-casomorphin-7 (bBCM-7) and the activity of dipeptidyl peptidase-IV (DPPIV) in sera of infants with apparent life threatening events (ALTE syndromes, 'near miss SIDS'). We have found that the sera of some infants after an apnoea event contained more beta-casomorphin-7 than that of the healthy infants in the same age. In all the children after an apnoea event, however, a lowered DPPIV was detected. We suspect that the low activity of that peptidase may be responsible for opioid-induced respiratory depression, induced by bBCM-7 in the general circulation. (C) 2011 Elsevier Ltd. All rights reserved.