Categorization of behavioural sequences in the prefrontal cortex
Categorization of behavioural sequences in the prefrontal cortex
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DOI：
10.1038/nature05470
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发表时间：
2007-01
期刊：
影响因子：
64.8
通讯作者：
K. Shima;Masaki Isoda;H. Mushiake;J. Tanji
中科院分区：
文献类型：
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作者：
K. Shima;Masaki Isoda;H. Mushiake;J. Tanji
虽然长期以来，人们一直认为灵长类动物的前额叶皮质参与了行为的综合调控，但认知行为规划的具体方面背后的神经结构尚不清楚。如果要求受试者记住大量复杂的运动序列并计划单独执行它们中的每一个，则根据序列的每个子集中固有的特定时间结构对序列进行分类有助于基于记忆的更高级别的规划。在这里，我们使用这些要求表明，外侧前额叶皮质的细胞选择性地展示特定类别的行为序列的活动，以及由不同类型的运动序列体现的行为类别在计划过程中在前额叶细胞中表现出来。这种细胞活动意味着能够在抽象水平上存储结构化事件复合体的神经表征的产生，例证了外侧前额叶皮质宏观结构化动作知识的发展。
Although it has long been thought that the prefrontal cortex of primates is involved in the integrative regulation of behaviours,,,, the neural architecture underlying specific aspects of cognitive behavioural planning has yet to be clarified,,,. If subjects are required to remember a large number of complex motor sequences and plan to execute each of them individually, categorization of the sequences according to the specific temporal structure inherent in each subset of sequences serves to facilitate higher-order planning based on memory. Here we show, using these requirements, that cells in the lateral prefrontal cortex selectively exhibit activity for a specific category of behavioural sequences, and that categories of behaviours, embodied by different types of movement sequences, are represented in prefrontal cells during the process of planning. This cellular activity implies the generation of neural representations capable of storing structured event complexes at an abstract level, exemplifying the development of macro-structured action knowledge in the lateral prefrontal cortex.