Modeling of mosaic patterns in chimeric liver and adrenal cortex: algorithmic organogenesis?
Modeling of mosaic patterns in chimeric liver and adrenal cortex: algorithmic organogenesis?
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DOI：
10.1096/fasebj.14.5.823
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发表时间：
2000-04-01
期刊：
影响因子：
4.8
通讯作者：
Iannaccone, PM
中科院分区：
文献类型：
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作者：
Landini, G;Iannaccone, PM
如果器官发生是一个完全确定性的过程，那么存储脊椎动物生物体中每个细胞的空间位置和命运所需的信息量将大于其基因组中可能包含的全部信息，这表明参与器官发生的发育机制的指令，编码iu DNA，必须至少部分基于程序或算法。大鼠肝脏中的嵌合体镶嵌图案已被证明是各向同性的，并具有分形轮廓（D类似于1.3），而肾上腺镶嵌显示出不太不规则的放射状图案，具有较低的分形维数（D类似于1.2）比肝脏。这些研究结果提出了一个可能的模型的实质生成，我们提出，在器官形成过程中，在肝脏和肾上腺皮质，相同的基本机制是针对器官质量的扩大，而观察到的器官之间的马赛克模式的差异可能是由于控制一个单一的参数，即，一种形式的接触抑制。计算机模拟在两个维度返回可比的结果，在镶嵌补丁的分形维数值和外观的镶嵌“组织”，在嵌合体的组织学观察。这表明，在嵌合体中观察到的镶嵌图案不需要细胞的位置信息和运动。
If organogenesis were a completely deterministic process, then the amount of information required to store the spatial position and fate of every cell in vertebrate organisms would be larger than the total information that could be contained in their genomes, This suggests that the instructions of developmental mechanisms involved in organogenesis, coded iu DNA, must be at least in part procedural or algorithmically based. Chimeric mosaic patterns in rat livers have been shown to be isotropic and to have fractal profiles (D similar to 1.3) whereas adrenal gland mosaics show a less irregular radial pattern, with lower fractal dimension (D similar to 1.2) than in the liver. These findings suggested a possible model of parenchyma generation, We propose that during organogenesis in both liver and adrenal cortex, the same basic mechanism is directed to organ mass enlargement, whereas the differences observed in mosaic patterns between the organs could be due to the control of a single parameter, namely, a form of contact inhibition. Computer simulations in two dimensions returned comparable results in both the fractal dimension value of mosaic patches and appearance of the mosaic 'tissues', as observed histologically in chimeras. This suggests that position information and locomotion of cells would not be required to produce the mosaic pattern observed in chimeras.