Protein Array-based Approaches for Biomarker Discovery in Cancer.
Protein Array-based Approaches for Biomarker Discovery in Cancer.
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DOI：
10.1016/j.gpb.2017.03.001
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Zhu H
中科院分区：
文献类型：
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作者：
Huang Y;Zhu H
生物标志物被认为是癌症早期诊断、治疗监测和预后评估的潜在工具，与计算机断层扫描和活检相比具有简单和经济的优势。然而，目前大多数癌症生物标志物的灵敏度和特异性不足。因此，迫切需要发现癌症的生物标志物。蛋白质芯片技术是近年来发展起来的一种新技术，它具有微型化、高通量、高灵敏度等优点，为癌症蛋白质组学研究提供了一个通用的、强大的平台。本文就不同类型的蛋白质芯片在肿瘤生物标志物发现中的应用特点和进展作一较为全面的介绍，并对该领域的研究前景进行展望。
Biomarkers are deemed to be potential tools in early diagnosis, therapeutic monitoring, and prognosis evaluation for cancer, with simplicity as well as economic advantages compared with computed tomography and biopsy. However, most of the current cancer biomarkers present insufficient sensitivity as well as specificity. Therefore, there is urgent requirement for the discovery of biomarkers for cancer. As one of the most exciting emerging technologies, protein array provides a versatile and robust platform in cancer proteomics research because it shows tremendous advantages of miniaturized features, high throughput, and sensitive detections in last decades. Here, we will present a relatively complete picture on the characteristics and advance of different types of protein arrays in application for biomarker discovery in cancer, and give the future perspectives in this area of research.