Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
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DOI：
10.1016/s1470-2045(07)70140-7
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发表时间：
2007-05-01
期刊：
影响因子：
51.1
通讯作者：
Munn, Lance L.
中科院分区：
文献类型：
--
作者：
Bockhorn, Maximilian;Jain, Rakesh K.;Munn, Lance L.
虽然每天有数百万个细胞从肿瘤中脱落，但认为血行转移是非常低效的。这种低效率被广泛认为是血流中的细胞被剪切应力和免疫系统破坏的结果，以及在次级部位的基质中渗出和增殖的缓慢速率。在这里，我们提出，而主动内渗的细胞进入循环是重要的，在某些肿瘤，其他可能脱落细胞被动进入血液或淋巴管，而不涉及主动细胞迁移。我们讨论了支持和反对这种被动脱落假说的证据以及对未来治疗的影响。
Although millions of cells are shed from a tumour every day, haematogenous metastasis is believed to be very inefficient. This inefficiency is widely assumed to be a result of the destruction of cells in the bloodstream by shear stress and the immune system and a slow rate of extravasation and proliferation in the stroma at a secondary site. Here, we propose that, whereas active intravasation of cells into the circulation is important in some tumours, others might shed cells passively into the blood or lymphatic vessels without the involvement of active cell migration. We discuss the evidence for and against this passive-shedding hypothesis and the implications for future treatments.