Childhood trauma and psychosis-Searching for causes and mechanisms.
Childhood trauma and psychosis-Searching for causes and mechanisms.
复制标题
童年创伤和精神病——寻找原因和机制。
DOI：
10.1016/j.schres.2023.11.004
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发表时间：
2023
影响因子：
4.5
通讯作者：
Keshavan,MatcheriS
中科院分区：
文献类型：
--
作者：
DelRe,ElisabettaC;Keshavan,MatcheriS
对B文章的评论。Kerková等人(see记录2024-26258-030）。Kerková等人最近在该杂志上报道，CHT显着缓和炎症增加和认知结果之间的关系，在认知领域具有一定的特异性。我们同意，并认为遗传学，表观遗传因素（EP），药物滥用和其他健康的社会决定因素也可能在发挥作用，在演唱会，或在级联的多击中病因过程。此外，炎症可能是与其他过程相互作用或介导其他过程的机制之一，例如在导致精神病理学的病理生理级联反应中的肾上腺能功能、下丘脑-垂体-肾上腺轴和氧化应激的改变，所述精神病理学不仅包括认知障碍，还包括精神病和抑郁症状。造成精神分裂症和相关精神障碍的其他社会决定因素包括贫穷、族裔歧视、族裔密度低、移徙、社会分裂和无家可归。这些观察结果与SZ和其他精神疾病的多重打击模型基本一致，强调了在几个时间点进行干预的可能性。遗传学研究结果表明，精神疾病和功能结果的风险在很大程度上重叠，CHT作为精神病轨迹中的第一击的重要作用。（PsycInfo数据库记录（c）2024阿帕，保留所有权利）
Comments on an article by B. Kerková et al.(see record 2024-26258-030). Kerková et al. recently reported in this Journal that CHT significantly moderates the relationship between increased inflammation and cognitive outcome, with some specificity across cognitive domains. We agree, and would argue that genetics, epigenetic factors (EP), substance abuse and other social determinants of health may also be at play in concert with, or in a cascade of multi-hit etiological processes. Additionally, inflammation may be one of the mechanisms that interacts with or mediates other processes such as alterations in glutamatergic function, hypothalamic-pituitary adrenal axis and oxidative stress in the pathophysiological cascade that leads to psychopathology which includes not only cognitive impairments but also psychosis and depressive symptoms. Other social determinants of causation of schizophrenia and related psychotic disorders include poverty, ethnic discrimination, low ethnic density, migration, social fragmentation and homelessness. These observations are in general consistent with the multiple hit models of SZ and other mental illnesses, which highlight the possibility of intervention at several timepoints. Genetics findings suggest largely overlapping risk across mental diseases and functional outcomes, and an important role of CHT as a first hit in the trajectory toward psychosis.(PsycInfo Database Record (c) 2024 APA, all rights reserved)