Local hyperthermia with interstitial techniques.
Local hyperthermia with interstitial techniques.
复制标题
采用间质技术进行局部热疗。
作者：
I. Brezovich;W. Atkinson;M. Lilly
研究了植入电极和自调节铁磁热籽对深部内脏肿瘤的加热作用。对六名植入电极加热的患者进行的临床试验表明，在正常的放射治疗过程中，通过应用热疗可以获得良好的局部肿瘤控制。加热方法被发现是实用的，既没有毒性，也没有严重的患者不适。然而，肿瘤体积内的温度不均匀性仍然是一个问题。理论研究和动物实验表明，用70.4%镍和29.6%铜的合金制成的热籽加热肿瘤，可以大大改善温度均匀性。在居里点附近，这种材料的产热率高度依赖于温度，大约为50度，提供了自动温度调节。
The heating of deep visceral tumors with implanted electrodes and with self-regulating ferromagnetic thermoseeds was investigated. Clinical trials on six patients heated with implanted electrodes indicate that good local tumor control can be obtained by application of hyperthermia during a normal course of radiotherapy. The heating method was found practical, and neither toxicity nor severe patient discomfort was encountered. However, temperature inhomogeneity within the tumor volume remains a problem. Theoretical studies and an animal experiment indicate that temperature homogeneity can be largely improved by heating the tumor with thermoseeds made of an alloy of 70.4% nickel and 29.6% copper. The highly temperature-dependent rate of heat production in the vicinity of the Curie point, about 50 degrees for this material, provides automatic temperature regulation.