CELL DISTRIBUTION DIFFERENCES OF MATRIX METALLOPROTEINASE-9 AND TISSUE INHIBITOR OF MATRIX METALLOPROTEINASE-1 IN PATIENTS WITH KAWASAKI DISEASE
CELL DISTRIBUTION DIFFERENCES OF MATRIX METALLOPROTEINASE-9 AND TISSUE INHIBITOR OF MATRIX METALLOPROTEINASE-1 IN PATIENTS WITH KAWASAKI DISEASE
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DOI：
10.1097/inf.0b013e31825ba6b3
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发表时间：
2012-09-01
影响因子：
3.6
通讯作者：
Izumi, Tatsuro
中科院分区：
文献类型：
--
作者：
Korematsu, Seigo;Ohta, Yoko;Izumi, Tatsuro
基质金属蛋白酶（MMP）-9和基质金属蛋白酶组织抑制剂-1的相互作用与川崎冠状动脉瘤的形成有关。MMP-9和基质金属蛋白酶组织抑制剂-1主要分布在粒细胞和血小板，分别在川崎病患者。MMP-9的血浆值与循环中性粒细胞计数呈正相关。抑制粒细胞活性，维持血小板活性，可预防冠状动脉瘤的发生。
The interaction of matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase-1 has been implicated in the formation of coronary aneurysms in Kawasaki disease. MMP-9 and tissue inhibitor of matrix metalloproteinase-1 were distributed predominantly in the granulocytes and platelets, respectively, in patients with Kawasaki disease. The plasma values of MMP-9 correlated positively with the circulating neutrophil count. Inhibiting the activity of granulocytes and maintaining the platelet activity might prevent coronary aneurysms.