Acquired tick resistance: The trail is hot.
Acquired tick resistance: The trail is hot.
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获得蜱虫抗药性： 踪迹炙手可热。
DOI：
10.1111/pim.12808
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发表时间：
2021-05
影响因子：
2.2
通讯作者：
Fikrig E
中科院分区：
文献类型：
--
作者：
Narasimhan S;Kurokawa C;DeBlasio M;Matias J;Sajid A;Pal U;Lynn G;Fikrig E
获得性蜱抗性是一种现象，其中宿主在反复蜱侵染时激发针对蜱唾液组分的免疫应答。免疫反应可能直接针对关键的唾液成分，阻止蜱虫进食，动物对随后的蜱虫感染产生抵抗力。当蜱虫以非天然宿主为食时，经常观察到蜱虫抗药性的发展，而不是天然宿主。导致蜱抗药性发展的分子机制尚未完全了解，宿主和蜱因子都参与了这一现象。解决宿主和蜱虫的分子工具的进展开始揭示对这一现象的新见解，并揭示对蜱虫-宿主相互作用的基础生物学的更深入理解。本综述将重点关注对获得性蜱抗性的不断扩大的理解，并强调这种理解对抗蜱疫苗开发工作的影响。
Acquired tick resistance is a phenomenon wherein the host elicits an immune response against tick salivary components upon repeated tick infestations. The immune responses, potentially directed against critical salivary components, thwart tick feeding, and the animal becomes resistant to subsequent tick infestations. The development of tick resistance is frequently observed when ticks feed on non‐natural hosts, but not on natural hosts. The molecular mechanisms that lead to the development of tick resistance are not fully understood, and both host and tick factors are invoked in this phenomenon. Advances in molecular tools to address the host and the tick are beginning to reveal new insights into this phenomenon and to uncover a deeper understanding of the fundamental biology of tick‐host interactions. This review will focus on the expanding understanding of acquired tick resistance and highlight the impact of this understanding on anti‐tick vaccine development efforts.
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影响因子：
2.2
作者：
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通讯作者：
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影响因子：
5.4
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通讯作者：
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影响因子：
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作者：
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通讯作者：
ASKENASE, PW