Toxicology update: the cardiotoxicity of the oxidative stress metabolites of catecholamines (aminochromes)
Toxicology update: the cardiotoxicity of the oxidative stress metabolites of catecholamines (aminochromes)
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DOI：
10.1002/jat.793
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发表时间：
2001-12-01
影响因子：
3.3
通讯作者：
Baskin, SI
中科院分区：
文献类型：
--
作者：
Behonick, GS;Novak, MJ;Baskin, SI
本毒理学更新回顾了儿茶酚胺的氧化应激代谢产物，被认为是心脏毒性的生化启动物。儿茶酚胺代谢的简要概述提供了几个值得注意的历史观察有关肾上腺素的自氧化和重排。讨论了肾上腺素色素和肾上腺素的基本化学和物理性质。综述了儿茶酚胺转化为氧化代谢物的自氧化、酶和细胞基础。本文描述了在孤立心脏灌注研究和体内模型中观察到的心脏毒性变化的机制。2001年由John Wiley Sons出版。
This toxicology update reviews the oxidative stress metabolites of catecholamines, postulated to be the biochemical initiators of cardiotoxicity. A brief overview of catecholamine metabolism is provided with several noteworthy historical observations relating to the autoxidation and rearrangement of epinephrine. The basic chemical and physical properties of adrenochrome and adrenolutin are discussed. The autoxidative, enzymatic and cellular basis for the transformation of catecholamines to oxidative metabolites is reviewed. Mechanisms seeking to account for the observed cardiotoxic changes in isolated heart perfusion studies and in vivo models are described. Published in 2001 by John Wiley Sons, Ltd.