Evidence of immune genes in the crinoïd: Antedon bifida evidence of A.bifida Igkappa gene and a FC receptor one

Evidence of immune genes in the crinoïd: Antedon bifida evidence of A.bifida Igkappa gene and a FC receptor one
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海百合中免疫基因的证据:Antedon bifida A.bifida Igkappa 基因和 FC 受体的证据一

DOI:
10.15406/jabb.2018.05.00154
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发表时间:
2018
期刊:
Journal of Applied Biotechnology & Bioengineering
影响因子:
--
通讯作者:
P. Grange
P. Grange
中科院分区:
--
文献类型:
--
作者:
M. Leclerc;F. Letourneur;D. Davoult;A. Jolly;P. Grange

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从我们实验室的实验中得出的一般观点是,棘皮动物,如海星星星Asterias rubens(Asterids)和Ophiocomina nigra(Ophuirids),拥有免疫系统,能够产生细胞和体液特异性反应。在用外源抗原刺激后:辣根过氧化物酶(HRP)。1,2然后,这些棘皮动物产生了一种原始抗体,与Igkappa基因3 -5 Fab基因,6 Fc受体基因7相关。但是一个问题必须提出:祖先棘皮动物,Antedon bifida,(Crinoïd)是否拥有这样的基因?因此,我们首次通过基因组学的方法,在该海百合中寻找IgKappa基因、Fab基因、Fc受体基因。
The general idea that emerged from the experiments, made in our laboratory, was that Echinodermata, as exemplified, by sea star Asterias rubens (Asterids)and by Ophiocomina nigra (Ophuirids), possessed an immune system, able to mount cellular and humoral-specific responses. After stimulation with a foreign antigen:the horse-radish peroxydase(HRP).1,2 Then,these echinodermata produced a primitive antibody, correlated to an Igkappa gene3–5 to a Fab gene,6 a Fc receptor gene.7 But a question desserves to be put: did the ancestral Echinodermata, Antedon bifida, (Crinoïd) possess such genes? It is why, in a first time, we look for IgKappa gene, Fab gene, Fc receptor gene in this crinoïd by the mean of genomic studies.