BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine.
BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine.
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BATMAN-TCM：中药分子机制生物信息学分析工具
DOI：
10.1038/srep21146
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发表时间：
2016-02-16
影响因子：
4.6
通讯作者：
He F
中科院分区：
文献类型：
--
作者：
Liu Z;Guo F;Wang Y;Li C;Zhang X;Li H;Diao L;Gu J;Wang W;Li D;He F
中医药已有几千年的临床实践历史，在世界范围内得到越来越多的重视和应用。而以中医药为基础的新药开发，特别是对复杂疾病的治疗前景广阔。然而，由于中药成分的多样性和与人体的复杂相互作用，其分子机制仍很难被揭示，这极大地阻碍了中医药的现代化和国际化。在这里，我们开发了第一个用于中医分子机制的在线生物信息学分析工具(蝙蝠侠-中医)。其主要功能包括：1)中药成分的靶点预测；2)靶点的功能分析，包括生物通路、基因本体论功能术语和疾病浓缩分析；3)药材-靶点-通路/疾病关联网络和KEGG生物通路的可视化，突出靶点；4)多个中药的比较分析。最后，我们将蝙蝠侠中药应用于七参益气滴丸，并结合后续的实验验证，首次揭示了肾素-血管紧张素系统在奇神益气滴丸心脏保护作用中的作用。蝙蝠侠-中医将有助于理解中医的多成分、多靶点、多途径的组合治疗机制，并为后续的实验验证提供有价值的线索，加速阐明中医的分子机制。《蝙蝠侠-中药》在http://bionet.ncpsb.org/batman-tcm.上有售
Traditional Chinese Medicine (TCM), with a history of thousands of years of clinical practice, is gaining more and more attention and application worldwide. And TCM-based new drug development, especially for the treatment of complex diseases is promising. However, owing to the TCM’s diverse ingredients and their complex interaction with human body, it is still quite difficult to uncover its molecular mechanism, which greatly hinders the TCM modernization and internationalization. Here we developed the first online Bioinformatics Analysis Tool for Molecular mechANism of TCM (BATMAN-TCM). Its main functions include 1) TCM ingredients’ target prediction; 2) functional analyses of targets including biological pathway, Gene Ontology functional term and disease enrichment analyses; 3) the visualization of ingredient-target-pathway/disease association network and KEGG biological pathway with highlighted targets; 4) comparison analysis of multiple TCMs. Finally, we applied BATMAN-TCM to Qishen Yiqi dripping Pill (QSYQ) and combined with subsequent experimental validation to reveal the functions of renin-angiotensin system responsible for QSYQ’s cardioprotective effects for the first time. BATMAN-TCM will contribute to the understanding of the “multi-component, multi-target and multi-pathway” combinational therapeutic mechanism of TCM and provide valuable clues for subsequent experimental validation, accelerating the elucidation of TCM’s molecular mechanism. BATMAN-TCM is available at http://bionet.ncpsb.org/batman-tcm.