Intracerebroventricular administration of mouse leptin does not reduce food intake in the chicken
Intracerebroventricular administration of mouse leptin does not reduce food intake in the chicken
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DOI：
10.1016/s0006-8993(98)01223-2
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发表时间：
1999-01-30
期刊：
影响因子：
2.9
通讯作者：
Furuse, M
中科院分区：
文献类型：
--
作者：
Bungo, T;Shimojo, M;Furuse, M
近年来研究表明，瘦素在大鼠和小鼠的摄食和代谢中起着重要的调节作用，但中枢给予瘦素对雏鸡摄食的影响尚未见报道。我们已经研究了瘦素通过脑室内（i.c.v.）注射鸡使用小鼠瘦素，显示97%的同源性鸡瘦素。进行了三个实验。在禁食3小时后，通过i.c.v.注射以0、0.2、1.0和5.0 μ g（实验1）或0、2.5和5.0 μ g（实验2）的剂量水平给予雄性肉鸡瘦素。在处理后2 h（实验1）和24 h（实验2），允许鸡自由进食饲料。在实验3中使用雄性单冠白色来航鸡，并以与实验1相同的方式进行处理。在所有的实验中，小鼠瘦素的中央给药在检查的时间段内不影响食物摄入。看来，小鼠瘦素不结合鸡瘦素受体或在鸡脑中的瘦素受体可能不存在。(C)1999 Elsevier Science B.V.
Recently, it has been suggested that leptin plays an important role in regulation of food intake and metabolism in rats and mice, however, the effect of central administration of leptin on food intake in chicks has not been reported. We have investigated the anorexigenic effect of leptin administered by intracerebroventricular (i.c.v.) injection in chicks using mouse leptin, which shows 97% homology to chicken leptin. Three experiments were conducted. After being deprived of food for 3 h, male broiler chicks were administered leptin by i.c.v. injection at dose levels of 0, 0.2, 1.0 and 5.0 mu g (Experiment 1) or 0, 2.5 and 5.0 pg (Experiment 2). The birds were allowed free access to the diet for 2 h (Experiment 1) and 24 h (Experiment 2) after treatment. Male Single Comb White Leghorn chicks were used in Experiment 3 and were treated in the same manner as in Experiment 1. In all experiments, central administration of mouse leptin did not influence food intake in the time periods examined. It appears that either mouse leptin does not bind to the chicken leptin receptor or in the chicken brain the leptin receptor may be absent. (C) 1999 Elsevier Science B.V.