All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts.
All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts.
复制标题
并非所有多不饱和脂肪酸都是一样的：在随机对照试验和前瞻性观察队列中，亚油酸不具有特定的冠心病益处。
DOI：
10.1159/000327789
复制
发表时间：
2011
影响因子：
--
通讯作者：
Majchrzak-Hong,SharonF
中科院分区：
文献类型：
--
作者：
Ramsden,ChristopherE;Hibbeln,JosephR;Majchrzak-Hong,SharonF
Advice to maintain or increase consumption of the omega-6 polyunsaturated fatty acid (n–6 PUFA) linoleic acid (LA) should be derived from interventional and observational trials evaluating the specific effects of dietary LA, rather than effects of n–3 PUFAs or total PUFAs. Failure to make a clear distinction among PUFA species may result in inadvertently attributing health effects of n–3 PUFAs to linoleic acid. Pooled analyses of randomized controlled trials (RCTs) of clinical CHD events [1] and intermediate risk factors [2] and pooled analyses of nonrandomized prospective observational trials of clinical CHD events [3] are often cited as providing strong concordant evidence [1, 4] that LA is cardioprotective. These pooled analyses [1–3] form the primary basis for recent populationwide advice to maintain or increase n–6 PUFA [5–7]. However, total PUFA rather than n–6 LA, was defined as the independent variable for statistical calculations in all three pooled analyses [1–3](table 1), then interpreted as attributable to LA [4–8]. In this paper we:(1) establish that a clear distinction was not made between n–3 and n–6 PUFAs in pooled analyses of randomized and nonrandomized trials (tables 2, 3),(2) report whether a clear distinction was made between n–3 and n–6 PUFAs in each individual trial before pooling,(3) assess strengths and limitations of randomized and nonrandomized study designs for disentangling respective intakes of n–6 and n–3 PUFA species, and (4) highlight the necessity of making a clear distinction between PUFA species for interpreting the results of clinical trials and formulating dietary guidelines.
