Contrast opacification of left ventricular myocardium following intravenous administration of sonicated albumin microspheres.
Contrast opacification of left ventricular myocardium following intravenous administration of sonicated albumin microspheres.
复制标题
静脉注射超声白蛋白微球后左心室心肌的对比混浊。
DOI：
10.1016/0002-8703(91)90284-o
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发表时间：
1991
影响因子：
4.8
通讯作者：
Quiñones,MA
中科院分区：
文献类型：
--
作者：
SandersJr,WE;Cheirif,J;Desir,R;Zoghbi,WA;Hoyt,BD;Schulz,PE;Quiñones,MA
Albunex是一种新的超声心动图（2-D回声）造影剂，经静脉注射后可穿过肺血管。我们检查静脉注射Albunex是否导致心肌强度的变化足够大，从而产生时间强度曲线（tic）。30例轻度高血压患者分为3组，每组10人。每例患者静脉注射3次Albunex（第一组：0.01、0.03、0.04 cm3/kg；第二组：0.04、0.06、0.08 cm3/kg；第三组：0.08、0.1、0.12 cm3/kg），对照注射2次5%人血清白蛋白，同时进行二维超声成像（相控阵，尖端四室）。43次注射显示左心室完全混浊。数字化舒张末期图像的视频强度分析在43次注射中有20次产生心肌tic（总强度曲线和背景减影强度曲线）。目测43例中有10例心肌造影剂显影。心肌tic的检测与剂量相关（I组7例中有0例，II组18例中有9例，III组18例中有11例），且与左室混浊程度一致。在对照组注射白蛋白期间，没有观察到任何患者的心肌造影剂效果，也没有观察到任何注射Albunex未导致左心室混浊的患者。因此静脉注射Albunex可以同时检测到心肌混浊和良好的左心室混浊。讨论了观察到的心肌混浊的潜在意义。
Albunex is a new echocardiographic (2-D echo) contrast agent that traverses the pulmonary vasculature when injected intravenously in humans. We examined whether intravenous Albunex resulted in changes in myocardial intensity of sufficient magnitude to produce time intensity curves (TICs). Thirty mildly hypertensive patients were divided into three groups of 10. Each patient received three injections of intravenous Albunex (group I dosages: 0.01, 0.03, and 0.04 cm3/kg; group II: 0.04, 0.06, and 0.08 cm3/kg; group III: 0.08, 0.1, and 0.12 cm3/kg) and two control injections of 5% human serum albumin while imaging with 2-D echo (phased-array; apical four-chamber). Fourty-three injections showed complete opacification of the left ventricle. Videointensity analysis of digitized end-diastolic frames produced myocardial TICs (total as well as background-substracted intensity curves) in 20 of 43 injections. By visual inspection, a myocardial contrast effect was seen in 10 of 43 injections. Detection of myocardial TICs was dose-related (0 of 7 in group I, 9 of 18 in group II, 11 of 18 in group III) and always paralleled the degree of left ventricular opacification. No myocardial contrast effect was observed in any patient during control injections of albumin or in any patient in whom the injection of Albunex did not result in left ventricular opacification. Thus myocardial opacification with intravenous Albunex can be detected simultaneously with good left ventricular opacification. The potential significance of the myocardial opacification observed is discussed.