A review for cell-based screening methods in drug discovery.
A review for cell-based screening methods in drug discovery.
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DOI：
10.52601/bpr.2021.210042
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发表时间：
2021-12-31
影响因子：
--
通讯作者：
Gou X
中科院分区：
文献类型：
--
作者：
Wei F;Wang S;Gou X
随着全细胞的生物学相关性，与动物实验相比成本低，各种各样的基于细胞的筛选平台（基于细胞的分析，基于细胞的微流体，基于细胞的生物传感器，基于细胞的色谱）已经开发出来，以解决药物发现的挑战。在这篇综述中，我们总结了目前基于细胞的筛选的进展，并总结了不同应用平台的优缺点。挑战和改进策略相关的细胞为基础的方法也进行了讨论。
With the biological relevance of the whole cells, low cost compared with animal experiments, a wide variety of cell-based screening platforms (cell-based assay, cell-based microfluidics, cell-based biosensor, cell-based chromatography) have been developed to address the challenges of drug discovery. In this review, we conclude the current advances in cell-based screening and summary the pros and cons of the platforms for different applications. Challenges and improvement strategies associated with cell-based methods are also discussed.