Quantitative immunohistochemical analysis of mononuclear infiltrates in breast carcinomas–correlation with tumour differentiation
Quantitative immunohistochemical analysis of mononuclear infiltrates in breast carcinomas–correlation with tumour differentiation
复制标题
乳腺癌单核浸润的定量免疫组织化学分析——与肿瘤分化的相关性
作者：
A. Naukkarinen;K. Syrjänen
通过计算巨噬细胞的百分比来分析 76 例乳腺癌组织切片中的炎症浸润。 IgA + 和 IgG + 浆细胞、T 细胞及其亚群和自然杀伤细胞，并通过测量浸润内的毛细血管后微静脉（PCV，在 12 例病例中发现）。这些参数与核等级和生化测定的激素受体状态（已知的肿瘤分化标志物）相关。炎症程度与核分级呈正相关（P < 0.0001），炎症与雌激素受体（OR）阳性（P < 0.05）以及炎症与孕激素受体（PR）阳性（P < 0.05）呈负相关。当炎症从少量扩展到中度时，OKT8 + 抑制/细胞毒性 T 细胞的百分比增加（P < 0.02）。 PCV 的直径也随着炎症浸润的增加而增加（P < 0.02）。此外，PCV 的直径与 OKT8 + T 细胞 (P < 0.04) 和 Leu-7+ 自然杀伤细胞 (P < 0.03) 的百分比之间存在直接相关性。
Inflammatory infiltrates were analysed in tissue sections of 76 breast carcinomas by counting the percentage of macrophages. IgA + and IgG + plasma cells, Tcells with their subpopulations, and natural killer cells, and by measuring postcapillary venules (PCVs, found in 12 cases) within the infiltrates. These parameters were correlated with nuclear grade and biochemically determined hormone receptor status, known markers of tumour differentiation. A direct correlation was found between the extent of inflammation and nuclear grade (P< 0.0001), and an inverse correlation between inflammation and oestrogen receptor (OR) positivity (P< 0.05) as well as inflammation and progesterone receptor (PR) positivity (P < 0.05). The percentage of the OKT8 + suppressor/cytotoxic T cells increased when the inflammation expanded from scanty to moderate (P < 0.02). The diameter of the PCVs also increased with increasing inflammatory infiltrate (P < 0.02). In addition, a direct correlation exists between the diameter of the PCVs and both the percentage of the OKT8 + T cells (P < 0.04) and the Leu‐7+ natural killer cells (P < 0.03).
人乳腺癌中主要组织相容性抗原和炎症细胞浸润的免疫组织学特征。
DOI：
--
发表时间：
1983
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Bhan,AK;DesMarais,CL
通讯作者：
DesMarais,CL