Nucleosomes in the neighborhood New roles for chromatin modifications in replication origin control
Nucleosomes in the neighborhood New roles for chromatin modifications in replication origin control
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DOI：
10.4161/epi.6.5.15082
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发表时间：
2011-05-01
期刊：
影响因子：
3.7
通讯作者：
Cook, Jeanette Gowen
中科院分区：
文献类型：
--
作者：
Dorn, Elizabeth Suzanne;Cook, Jeanette Gowen
局部染色质结构在调节复制起始中的重要性已变得越来越明显。最近，组蛋白甲基化和核小体定位已被添加到已证明可调节起源的修饰列表中。特别是，H3K4、H3K36和H4K20的甲基化状态与建立活跃、抑制或平衡的起源相关，这取决于甲基化的时间和程度。核小体的稳定性和精确定位也被证明会影响复制效率。虽然目前还不清楚这些修改如何改变特定的复制因子的行为，充分的证据表明它们在维持协调复制中的作用。本文将总结最近的进展，了解这些方面的染色质结构在DNA复制起点控制。
The importance of local chromatin structure in regulating replication initiation has become increasingly apparent. Most recently, histone methylation and nucleosome positioning have been added to the list of modifications demonstrated to regulate origins. In particular, the methylation states of H3K4, H3K36 and H4K20 have been associated with establishing active, repressed or poised origins depending on the timing and extent of methylation. The stability and precise positioning of nucleosomes has also been demonstrated to affect replication efficiency. Although it is not yet clear how these modifications alter the behavior of specific replication factors, ample evidence establishes their role in maintaining coordinated replication. This review will summarize recent advances in understanding these aspects of chromatin structure in DNA replication origin control.