Development of Degaussing System of Magnetic Filters for High Gradient Magnetic Separation to Improve Recovery Ratio of Trapped Magnetic Nanobeads
Development of Degaussing System of Magnetic Filters for High Gradient Magnetic Separation to Improve Recovery Ratio of Trapped Magnetic Nanobeads
复制标题
开发用于高梯度磁分离的磁过滤器消磁系统以提高捕获的磁纳米珠的回收率
DOI：
10.1109/tasc.2013.2281364
复制
发表时间：
2014
影响因子：
1.8
通讯作者：
Shuichi Nakamura
中科院分区：
文献类型：
--
作者：
K. Kajikawa;H. Ueda;Y. Kamioka;K. Agatsuma;S. Fuchino;M. Furuse;T. Iitsuka;Shuichi Nakamura
We have successfully developed a high-gradient magnetic separation system for medical proteins using affinity magnetic nanobeads.我们的系统显示出非常高的分离效率，并且与传统系统相比，由于生产率更高，因此有望实现更低的成本。 The developed system consists of a 3-T superconducting magnet and a filter made of fine magnetic metal fibers. The superconducting magnet is wound with a NbTi twisted multifilamentary wire, and cooled by a 4-K Gifford-McMahon cryocooler.为了实现低温恒温器室温明腔中过滤器上捕获的磁性纳米珠的高回收率，过滤器的交流消磁系统采用由超导磁体和附加电容器串联组成的电感电容谐振电路构建。为了在超导磁体和电容器之间执行几个周期以上的电感-电容谐振，超导磁体在线轴上具有狭缝，以防止与交变磁场耦合的涡流。 It also has a control system for a high-speed switching circuit.由于磁体线轴上有狭缝，该磁体可以在 150 s 的相对较快扫描时间内，在直径 30 mm 的低温恒温器的通孔中成功产生 3.0 T 的磁场。 Using our degaussing system, a high recovery ratio of the nanobeads in pure water has been performed about 94.1%.
We have successfully developed a high-gradient magnetic separation system for medical proteins using affinity magnetic nanobeads. Our system shows very high separation efficiency and can also be expected to realize lower cost due to larger production rate compared to the conventional system. The developed system consists of a 3-T superconducting magnet and a filter made of fine magnetic metal fibers. The superconducting magnet is wound with a NbTi twisted multifilamentary wire, and cooled by a 4-K Gifford-McMahon cryocooler. In order to achieve high recovery ratio of the magnetic nanobeads trapped on the filter located in a room-temperature clear bore of the cryostat, the ac degaussing system for the filter is fabricated using an inductance-capacitance resonance circuit composed of a series connection with the superconducting magnet and an additional capacitor. To perform the inductance-capacitance resonance more than a few cycles between superconducting magnet and capacitor, the superconducting magnet has a slit in the bobbin to prevent an eddy current coupled with an alternating magnetic field. It also has a control system for a high-speed switching circuit. This magnet can successfully generate a magnetic field of 3.0 T in the clear bore of the cryostat with a diameter of 30 mm in a relatively fast sweep time of 150 s due to the slit in the magnet bobbin. Using our degaussing system, a high recovery ratio of the nanobeads in pure water has been performed about 94.1%.