UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide
UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide
复制标题
DOI：
10.1038/sj.jid.5701058
复制
发表时间：
2008-02-01
影响因子：
6.5
通讯作者：
Halliday, Gary M.
中科院分区：
文献类型：
--
作者：
Damian, Diona L.;Patterson, Clare R. S.;Halliday, Gary M.
紫外线辐射诱导的免疫抑制增强皮肤癌的发生。尽管防晒霜的使用越来越多，但皮肤癌的发病率仍在继续增加，防晒霜在预防免疫抑制方面不如晒伤有效。使用Mantoux反应作为皮肤免疫模型，我们研究了太阳模拟（ss）UV及其组分UVA和UVB波段的影响，并测试了局部烟酰胺保护免受UV诱导的免疫抑制的能力。对健康的Mantoux阳性志愿者的背部进行紫外线照射，以随机、双盲的方式将5%烟酰胺或溶剂应用于不同部位。随后在辐照和邻近未辐照部位进行的Mantoux试验能够测量含和不含烟酰胺的UV诱导的免疫抑制。亚红层ssUV造成显着的免疫抑制，虽然组件UVB和UVA剂量独立交付没有。男性免疫抑制ssUV剂量比女性免疫抑制所需的剂量低三倍。这可能是男性皮肤癌发病率和死亡率较高的一个重要原因。局部烟酰胺预防免疫抑制，基因芯片微阵列表明，保护机制可能包括补体，能量代谢和凋亡途径的改变。烟酰胺是一种安全且廉价的化合物，可以添加到防晒霜或晒后乳液中，以提高对免疫抑制的保护。
UV radiation-induced immunosuppression augments cutaneous carcinogenesis. The incidence of skin cancer continues to increase despite increased use of sunscreens, which are less effective at preventing immunosuppression than sunburn. Using the Mantoux reaction as a model of skin immunity, we investigated the effects of solar-simulated ( ss) UV and its component UVA and UVB wavebands and tested the ability of topical nicotinamide to protect from UV-induced immunosuppression. Healthy, Mantoux-positive volunteers were UV-irradiated on their backs, with 5% nicotinamide or vehicle applied to different sites in a randomized, double-blinded manner. Subsequent Mantoux testing at irradiated and adjacent unirradiated sites enabled measurement of UV-induced immunosuppression with and without nicotinamide. Suberythemal ssUV caused significant immunosuppression, although component UVB and UVA doses delivered independently did not. Men were immunosuppressed by ssUV doses three times lower than those required to immunosuppress women. This may be an important cause of the higher skin cancer incidence and mortality observed in men. Topical nicotinamide prevented immunosuppression, with gene chip microarrays suggesting that the mechanisms of protection may include alterations in complement, energy metabolism and apoptosis pathways. Nicotinamide is a safe and inexpensive compound that could be added to sunscreens or after-sun lotions to improve protection from immunosuppression.