Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity
Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity
复制标题
DOI：
10.1016/s0041-0101(99)00108-7
复制
发表时间：
1999-11-01
期刊：
影响因子：
2.8
通讯作者：
Murray, TF
中科院分区：
文献类型：
--
作者：
Berman, FW;Gerwick, WH;Murray, TF
Curacin-A、抗龟毒素和钩毒素是来自海洋蓝藻 Lyngbya majuscula 的天然产物，在大鼠小脑颗粒神经元的原代培养物中测试了神经毒性。 Curacin-A 无毒，而抗龟毒素和钩毒素产生浓度依赖性细胞毒性，LC50 值分别为 20.1 +/- 6.4 和 3.86 +/- 1.91 nM。抗龟毒素的神经毒性是急性产生的，而钩毒素则引起延迟的神经毒性反应。非竞争性 NMDA 受体拮抗剂右啡烷和 MK-801 可以防止抗龟毒素和钩毒素产生的细胞毒性。 (C) 1999 Elsevier Science Ltd. 保留所有权利。
Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1 +/- 6.4 and 3.86 +/- 1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. (C) 1999 Elsevier Science Ltd. All rights reserved.