Emergent tuning for learned vocalizations in auditory cortex
Emergent tuning for learned vocalizations in auditory cortex
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DOI：
10.1038/s41593-019-0458-4
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发表时间：
2019-09-01
影响因子：
25
通讯作者：
Woolley, Sarah M. N.
中科院分区：
文献类型：
--
作者：
Moore, Jordan M.;Woolley, Sarah M. N.
声乐学习者利用早期的社会经验来发展专门用于交流的听觉技能。然而，目前尚不清楚在听觉通路中的哪个神经反应对发声有选择性，以及潜在的编码机制如何随着经验而变化。我们在两种鸣禽中使用了一种声乐辅导操作，以揭示在初级听觉皮层回路中出现了对同一种歌曲的调谐。初级听觉皮层深层区域的神经元对同种歌曲的反应比对其他物种的歌曲的反应更强，对物种典型的光谱时间调节的反应更强，但中间（丘脑受体）区域的神经元没有反应。此外，从其他物种学习歌曲的鸟类在深层而不是中间区域表现出对导师物种歌曲的选择性和调谐的平行变化。我们的研究结果定位了听觉处理层次结构中的一个区域，在这个区域中，经验依赖的编码机制将听觉反应与习得的发声运动行为的输出相一致。
Vocal learners use early social experience to develop auditory skills specialized for communication. However, it is unknown where in the auditory pathway neural responses become selective for vocalizations or how the underlying encoding mechanisms change with experience. We used a vocal tutoring manipulation in two species of songbird to reveal that tuning for conspecific song arises within the primary auditory cortical circuit. Neurons in the deep region of primary auditory cortex responded more to conspecific songs than to other species' songs and more to species-typical spectrotemporal modulations, but neurons in the intermediate (thalamorecipient) region did not. Moreover, birds that learned song from another species exhibited parallel shifts in selectivity and tuning toward the tutor species' songs in the deep but not the intermediate region. Our results locate a region in the auditory processing hierarchy where an experience-dependent coding mechanism aligns auditory responses with the output of a learned vocal motor behavior.