New methods for anion recognition and signaling using nanoscopic gatelike scaffoldings
New methods for anion recognition and signaling using nanoscopic gatelike scaffoldings
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DOI：
10.1002/anie.200602045
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Amoros, Pedro
中科院分区：
文献类型：
--
作者：
Casasus, Rosa;Aznar, Elena;Amoros, Pedro
在过去十年中，人们对阴离子分子识别的兴趣不断增长。[1]阴离子在生物和环境过程中发挥的突出作用促使研究人员研究基于超分子概念的许多受体的设计和合成。 [2]阴离子化学领域的一个新兴分支学科是阴离子信号传导方案的开发。这些系统中的大多数旨在观察阴离子协调时颜色或荧光或两者的调谐变化。 [3]在阴离子化学传感器的设计中已经描述了几种方法，但大多数方法都是基于使用通常共价连接的合适的结合位点（或反应位点）和信号单元（即合适的染料）。 [3]信号单元是发色团，而结合位点被设计为选择性地协调某种阴离子。这种方法被广泛使用，但存在一定的局限性。例如，许多阴离子结合位点受到水的强大氢键能力的竞争，并且许多需要具有挑战性的合成路线，特别是当目标是选择性识别非常相似的客体时。除了这种有点经典的分子方法之外，我们还有兴趣寻找阴离子识别和信号传导的新方法。一些突出的例子涉及将超分子化学与源自材料科学的概念相结合。 [4]例如，最近的研究表明，通过使用表面具有预组织荧光部分的功能化二氧化硅纳米粒子，可以实现协同信号放大。 [5]在不同的背景下，我们
In the last ten years, interest in the molecular recognition of anions has grown.[1] The prominent roles that anions play in biological and environmental processes prompted researchers to investigate the design and synthesis of a number of receptors based on supramolecular concepts.[2] An emerging subdiscipline of the field of anion chemistry is the development of anion signaling protocols. Most of these systems are designed to observe tuned changes in color or fluorescence or both upon anion coordination.[3] Several approaches have been described in the design of anion chemosensors, but most of them are based on the use of suitable binding sites (or reactive sites) and signaling units (ie, suitable dyes) that are usually covalently attached.[3] The signaling unit is a chromophore, whereas the binding site is designed to selectively coordinate a certain anion. This approach is widely used, but one that harbors certain limitations. For example, many anion-binding sites suffer competition from the strong hydrogen-bonding ability of water and many demand challenging synthetic routes, especially when the aim is the selective recognition of very similar guests. In addition to this somewhat classical molecular approach, we are interested in seeking new methods for anion recognition and signaling. Some prominent examples involve the blending supramolecular chemistry with concepts derived from materials science.[4] For example, recently it was shown that cooperative signal amplification could be obtained by using functionalized silica nanoparticles with pre-organized fluorescent moieties at the surface.[5] In a different context, we