High Resolution Microultrasound (µUS) Investigation of the Gastrointestinal (GI) Tract.
High Resolution Microultrasound (µUS) Investigation of the Gastrointestinal (GI) Tract.
复制标题
胃肠道 (GI) 的高分辨率显微超声 (μUS) 检查。
DOI：
10.1007/978-1-4939-6911-1_34
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Anbarasan T
中科院分区：
文献类型：
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作者：
Anbarasan T
胃肠道(GI)的高分辨率显微超声(μUS)扫描有可能成为一种重要的跨壁成像手段来辅助诊断。与传统的临床超声仪器相比，μUS的工作频率更高，能够提供更高分辨率的胃肠道扫描图像。为了研究μUS在这一应用中的应用，在伦理指导下，最重要的是，在组织学上类似于人类胃肠道的成本效益的体模是必要的。因此，已经开发了一种利用猪小肠组织的体模，用于定制组装的μUS扫描系统。两个这样的系统，步进式扫描仪和连续扫描扫描仪被用来重复扫描制备的猪小肠组织样本的区域。将猪小肠组织体模通过插入其肠系膜血管的套管注入脱气磷酸盐缓冲盐水(DPBS)溶液，以模拟体内条件，获得更好的μUS粘膜特征。μUS系统扫描整个组织体模的换能器以获取射频回波数据，然后使用MatLab进行处理。B超重建产生的2D图像具有映射到用户选择的颜色图的相对回声强度。开发的体模还允许进行修改，例如插入基准标记以检测组织随时间的变化以及同时进行灌注和扫描，为更详细地研究和调查μUS胃肠道扫描提供了一个平台。
High resolution, microultrasound (μUS) scanning of the gastrointestinal (GI) tract has potential as an important transmural imaging modality to aid in diagnosis. Operating at higher frequencies than conventional clinical ultrasound instruments, μUS is capable of providing scanned images of the GI tract with higher resolution. To investigate the use of μUS for this application, a phantom which is cost effective, within ethical guidelines and, most importantly, similar in histology to the human GI tract is necessary. Therefore, a phantom utilizing porcine small bowel tissue has been developed for custom assembled μUS scanning systems. Two such systems, astepping scanner and a continuous sweep scanner were utilized to repeatedly scan regions of prepared samples of porcine small bowel tissue. The porcine small bowel tissue phantom was perfused with degassed phosphate buffer saline (dPBS) solution through a cannula inserted in its mesenteric vessel to simulate in vivo conditions and achieve better μUS mucosal characterization. The μUS system scans a transducer across the tissue phantom to acquire RF echo data, which is then processed using MATLAB. A B-scan reconstruction produces 2D images with relative echo strength mapped to a color map of the user’s choice. The phantom developed also allows for modifications such as the insertion of fiducial markers to detect tissue change over time and simultaneous perfusion and scanning, providing a platform for more detailed research and investigation into μUS scanning of the GI tract.