Modulation of postjunctional α-adrenergic vasoconstriction during exercise and exogenous ATP infusions in ageing humans.
Modulation of postjunctional α-adrenergic vasoconstriction during exercise and exogenous ATP infusions in ageing humans.
复制标题
老年人运动和外源 ATP 输注期间结后 α-肾上腺素能血管收缩的调节。
DOI：
10.1113/jphysiol.2010.204081
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Dinenno,FrankA
中科院分区：
文献类型：
--
作者：
Kirby,BrettS;Crecelius,AnneR;Voyles,WyattF;Dinenno,FrankA
Non‐technical summaryWhen muscles contract, a variety of signals interact and ultimately increase blood flow and oxygen delivery to the active muscle. However, when there is simultaneous activation of the sympathetic nervous system, noradrenaline (norepinephrine) is released which tries to cause vasoconstriction in the same blood vessels that are trying to relax (vasodilate). In young adults, we have shown that there is a unique ability of the contracting muscle to limit this vasoconstriction, and also that a circulating factor called ATP mimics the exercise response. In the present study, we demonstrate that older healthy adults have an impaired ability to limit the sympathetic vasoconstrictor signal during exercise; however, this ability is preserved when we administer ATP. Thus, if this impairment in the ability of contracting muscle to limit sympathetic vasoconstriction in older adults is related to ATP, we speculate that circulating levels of ATP may be impaired during exercise.
