Establishment of cell type by compartmentalized activation of a transcription factor.
Establishment of cell type by compartmentalized activation of a transcription factor.
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通过转录因子的区室激活来建立细胞类型。
DOI：
10.1126/science.1948031
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Losick,R
中科院分区：
文献类型：
--
作者：
Margolis,P;Driks,A;Losick,R
在芽胞形成过程的早期，枯草芽孢杆菌形成隔膜，将孢子囊分割成称为前孔和母细胞的子细胞。每个子细胞都有自己的染色体，但遵循不同的基因表达程序。前孔基因的差异表达现在被证明是由转录因子σF的区域化活性建立的。σ增强子是在隔膜之前产生的，但只在隔膜后的孢子囊的前孔隔室中活跃。σ因子受产孢子操纵子的产物控制，这可能是将其活性限制在一个子细胞的原因。
Early in the process of spore formation inBacillus subtilisa septum is formed that partitions the sporangium into daughter cells called the forespore and the mother cell. The daughter cells each have their own chromosome but follow dissimilar programs of gene expression. Differential gene expression in the forespore is now shown to be established by the compartmentalized activity of the transcription factor σF. The σFfactor is produced prior to septation, but is active only in the forespore compartment of the post-septation sporangium. The σFfactor is controlled by the products of sporulation operonsspoIIAandspoIIE, which may be responsible for confining its activity to one of the daughter cells.