Excitotoxic lesions restricted to the dorsal CA1 field of the hippocampus impair spatial memory and extinction learning in C57BL/6 mice
Excitotoxic lesions restricted to the dorsal CA1 field of the hippocampus impair spatial memory and extinction learning in C57BL/6 mice
复制标题
DOI：
10.1016/j.nlm.2008.05.008
复制
发表时间：
2008-09-01
影响因子：
2.7
通讯作者：
Dodart, Jean-Cosme
中科院分区：
文献类型：
--
作者：
Dillon, Gregory M.;Qu, Xianlu;Dodart, Jean-Cosme
最近对海马病变患者的研究表明，记忆障碍的程度与海马内损伤的程度成正比。特别是局限于CA1区损伤的患者表现为中度至重度的顺行性健忘症，只有轻微的逆行性健忘症。类似的结果也见于其他物种，如非人类灵长类动物和大鼠；然而，选择性损伤对CA1的影响尚未在小鼠中得到表征。在本研究中，我们研究了兴奋毒性（NMDA）损伤对小鼠背侧CA1学习和记忆表现的几个方面的影响。我们的数据表明，背侧CA1损伤小鼠在暴露于新环境时过度活跃，在y迷宫自发交替任务中存在空间工作记忆障碍，并在8臂空间辨别学习任务中表现出缺陷。受损小鼠能够获得操作性杠杆按压任务，但在这种食欲性操作范式中表现出灭绝学习缺陷。综上所述，我们的研究结果表明，小鼠背侧CA1的损伤会导致与其他物种相似的选择性学习和记忆表现缺陷，并扩展了先前的研究结果，表明该海马区域在空间信息处理和/或抑制反应处理中起关键作用。(C) 2008爱思唯尔公司版权所有。
Recent Studies in patients with hippocampal lesions have indicated that the degree of memory impairment is proportional to the extent of damage within the hippocampus. Particularly, patients with damage restricted to the CA1 field demonstrate moderate to severe anterograde amnesia with only slight retrograde amnesia. Comparable results are also seen in other species such as non-human primates and rats; however, the effect of selective damage to CA1 has not yet been characterized in mice. In the present study, we investigated the effects of excitotoxic (NMDA) lesions of dorsal CA1 on several aspects of learning and memory performance in mice. Our data indicate that dorsal CA1 lesioned mice are hyperactive upon exposure to a novel environment, have spatial working memory impairments in the Y-maze spontaneous alternation task, and display deficits in an 8-arm spatial discrimination learning task. Lesioned mice are able to acquire an operant lever-press task but demonstrate extinction learning deficits in this appetitive operant paradigm. Taken together, our results indicate that lesions to dorsal CA1 in mice induce selective learning and memory performance deficits similar to those observed in other species, and extend previous findings indicating that this region of the hippocampus is critically involved in the processing of spatial information and/or the processing of inhibitory responses. (C) 2008 Elsevier Inc. All rights reserved.