Genetic analysis of 29 Y-STR loci in the Chinese Han population from Shanghai
Genetic analysis of 29 Y-STR loci in the Chinese Han population from Shanghai
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上海汉族人群29个Y-STR基因座的遗传分析
DOI：
10.1016/j.fsigen.2017.11.003
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发表时间：
2018-01-01
影响因子：
3.1
通讯作者：
Xie, Jianhui
中科院分区：
文献类型：
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作者：
Zhou, Yuxiang;Shao, Chengchen;Xie, Jianhui
Y 染色体短串联重复序列 (Y-STR) 的分析提供了可用于法医调查和群体研究的重要信息。本研究对来自上海汉族人群的 843 名无关男性样本进行了 PowerPlex (R) Y23 系统 (PPY23) 和 Yfiler (TM) Plus 系统 (Yfiler plus) 中包含的 29 个 Y-STR 分型。除了先前研究中报道的无效等位基因、重复等位基因和中间等位基因之外，最初还观察到 DYS643 上有一个等位基因 10，其侧翼区域有 2 个碱基缺失。 29 个 Y-STR 的基因多样性 (GD) 值范围从 DYS438 的 0.4186 到 DYS385a/b 的 0.9653。两个常用单倍型集PPY23集和Yfiler plus集的单倍型多样性分别为0.999980和0.999997。使用Yfiler plus集估计的上海汉族人群与其他汉族人群之间的配对遗传距离略大于其他汉族人群之间的遗传距离。使用多维尺度 (MDS) 对全球 17 个人群之间的成对遗传距离进行可视化，展示了根据民族地理模式的人群分布。与 Yfiler 集相比，Yfiler plus 集对于这些测试人群似乎具有较高的人群区分能力。总而言之，这些结果可以为法医调查和群体研究提供有用的 Y-STR 信息。
The analysis of Y chromosomal short tandem repeats (Y-STRs) provides important information that can be used to forensic investigation and population studies. In this study, typing of 29 Y-STRs included in the PowerPlex (R) Y23 system (PPY23) and Yfiler (TM) Plus system (Yfiler plus) was performed on 843 unrelated male samples from Han population in Shanghai. Besides null, duplicate, and intermediate alleles reported in previous studies, an allele of 10 at DYS643 with a 2-base deletion in the flanking region was initially observed. The gene diversity (GD) values of the 29 Y-STRs range from 0.4186 at DYS438 to 0.9653 at DYS385a/b. The haplotype diversity of two commonly used haplotype sets, PPY23 set and Yfiler plus set is 0.999980 and 0.999997, respectively. Pairwise genetic distances between Han population in Shanghai and other Han populations estimated using Yfiler plus set are slightly larger than that between other Han populations. Visualization of pairwise genetic distances between 17 worldwide populations using multidimensional scaling (MDS) demonstrates the distribution of populations according to their ethno-geographic patterns. Compared with Yfiler set, Yfiler plus set appears to have a relatively high population discrimination capacity for these tested populations. Altogether, these results can provide useful information of Y-STRs for forensic investigation and population studies.