Nectins establish a checkerboard-like cellular pattern in the auditory epithelium
Nectins establish a checkerboard-like cellular pattern in the auditory epithelium
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Nectins 在听觉上皮细胞中建立棋盘状的细胞模式
DOI：
10.1126/science.1211158
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发表时间：
2011
期刊：
影响因子：
56.9
通讯作者：
(*:equal contribution)
中科院分区：
文献类型：
--
作者：
Togashi;H*;Kominami;K*.;Waseda;M.;Komura;H.;Miyoshi;J.;Takeichi;M.;Takai;Y.;(*:equal contribution)
生物模式无处不在，从蝴蝶翅膀上复杂的模式到巴洛克式的肾小管结构。这些模式反映了数百万种细胞以错综复杂但可重复的方式组织起来，以建立组织和器官。更值得注意的是，这些模式通常是通过未分化细胞的自我组装而出现的。对于生物学家来说，理解这种现象是如何发生的是一个关键的挑战。在本期的第1144页上，Togashiet等人暗示了在这一过程中凝集素黏附分子之间的相互作用。
Biological patterns are all around us, ranging from the complex patterns on butterfly wings to the baroque architecture of kidney tubules. These patterns reflect the organization of millions of cell types in intricate yet reproducible ways to build tissues and organs. Even more remarkable, these patterns often arise through the self-assembly of undifferentiated cells. Understanding how this occurs is a key challenge for biologists. On page 1144 in this issue, Togashiet al.implicate the interactions between nectin adhesion molecules in this process.