DISCHARGES OF INTERPOSITUS AND PURKINJE-CELLS OF THE CAT CEREBELLUM DURING LOCOMOTION UNDER DIFFERENT CONDITIONS
DISCHARGES OF INTERPOSITUS AND PURKINJE-CELLS OF THE CAT CEREBELLUM DURING LOCOMOTION UNDER DIFFERENT CONDITIONS
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DOI：
10.1113/jphysiol.1988.sp017130
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发表时间：
1988-06-01
影响因子：
5.5
通讯作者：
EDGLEY, SA
中科院分区：
文献类型：
--
作者：
ARMSTRONG, DM;EDGLEY, SA
1.在自由活动的猫上，用细胞外微电极研究了小脑前叶V小叶中间部浦肯野细胞和中间核内神经元的运动相关放电。所有研究的细胞在运动过程中有节奏地放电。2.将在水平运动带上以0.5 m/s的速度行走期间的放电与（a）以0.9 m/s的速度行走期间的放电进行比较（B）在0.5m/min的步行过程中，s，带向上倾斜30度（当步进持续时间变化不大但运动EMG增加70-100%时）。3.在30个浦肯野细胞的放电时间相对于前肢的步骤周期显示两种速度的步行之间没有重大差异。大多数细胞在更快的步行速度下以略高的总速率放电，但增加通常是适度的，平均仅为5.6脉冲/s（即增加8%）。峰值频率有时会出现较大幅度的增加，但平均值仅为11.9脉冲/秒（+11%）。最小频率的变化通常较小（平均增加0.3脉冲/s）。4.在21个间位神经元中，只有一个神经元的放电时间相对于步进周期在两种速度之间是不同的。像浦肯野细胞一样，大多数神经元在更高的速度下放电略快，但平均增加仅为5.5脉冲/秒（+8.5）。峰值放电率通常也显示出适度的增加（平均6.2脉冲/s; +6.5%），而最小频率几乎没有变化。5.在19个浦肯野细胞之间的比较走上坡路和平坦的只有一个显示出任何重大差异的放电相位;整体放电率平均只有1.3脉冲/秒（2%）更高的上坡运动。6.在21间位神经元放电相位显着不同的上坡和平坦的只有两个细胞。总体放电率平均略高上坡（3.5脉冲/秒; 6.7%）和峰值率通常也略有增加（平均6脉冲/秒; 7.7%）。平均而言，最低速率高出1.6脉冲/秒（+5%）。7.研究结果进行了讨论，目前的概念如何中间部分小脑可能有助于运动控制，它的结论是，神经元研究可能没有什么贡献，以确定活力的运动，稳步行走。
1. Extracellular microelectrodes were used in free-to-move cats to study the locomotor-related discharges of Purkinje cells in the intermediate part of lobule V of the cerebellar anterior lobe and of neurones in the underlying nucleus interpositus anterior. All cells studied discharged rhythmically during locomotion. 2. The discharges during walking at a speed of 0.5 m/s on a horizontal exercise belt were compared with those during (a) walking at 0.9 m/s (when the duration of the step cycle is shortened considerably and the amplitudes of the locomotor electromyograms (EMGs) recorded from flexor and extensor muscles of the limbs are markedly increased) and (b) during walking at 0.5 m/s with the belt tilted uphill by 30 deg (when step duration is little changed but locomotor EMGs are increased by 70-100%). 3. In each of thirty Purkinje cells the timing of the discharges relative to the forelimb step cycle showed no major difference between the two speeds of walking. Most cells discharged at slightly higher overall rates at the faster walking speed but the increase was usually modest, the average being only 5.6 impulses/s (i.e. and increase of 8%). Peak rates sometimes underwent larger increases but the average was only 11.9 impulses/s (+11%). Changes in minimum rate were generally small (an average increase of 0.3 impulses/s). 4. Among twenty-one interpositus neurones there was only one in which discharge timing relative to the step cycle was different between the two speeds. Like the Purkinje cells, most neurones discharged slightly faster at the higher speed but the average increase was only 5.5 impulses/s (+8.5). Peak firing rates also usually showed a modest increase (averaging 6.2 impulses/s; +6.5%) while minimum rates were little changed. 5. Among nineteen Purkinje cells compared between walking uphill and on the flat only one showed any major difference in discharge phasing; overall firing rates were on average only 1.3 impulses/s (2%) higher for uphill locomotion. 6. Among twenty-one interpositus neurones discharge phasing differed markedly between walking uphill and on the flat in only two cells. Overall discharge rates were on average slightly higher uphill (by 3.5 impulses/s; 6.7%) and peak rates also usually increased slightly (on average, by 6 impulses/s; 7.7%). Minimum rates were higher, on average, by 1.6 impulses/s (+5%). 7. The findings are discussed in relation to current notions of how the intermediate part of the cerebellum may contribute to movement control and it is concluded that the neurones studied probably make little contribution to determining the vigour of the movements of steady walking.